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| - | | + | #REDIRECT [[6yhw]] This PDB entry is obsolete and replaced by 6yhw |
| - | ==Complex of the FimH lectin with a beta-cyclodextrin C-linked alpha-D- mannoside in cocrystalised orthomrhombic crystals at 2.00 A resolution==
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| - | <StructureSection load='5ab1' size='340' side='right' caption='[[5ab1]], [[Resolution|resolution]] 1.96Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[5ab1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AB1 FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCD:BETA-CYCLODEXTRIN'>BCD</scene>, <scene name='pdbligand=HP6:HEPTANE'>HP6</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=TA5:2H-1,2,3-TRIAZOL-4-YLMETHANOL'>TA5</scene></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ab1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ab1 OCA], [http://pdbe.org/5ab1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ab1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ab1 PDBsum]</span></td></tr>
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| - | </table>
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| - | <div style="background-color:#fffaf0;">
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| - | == Publication Abstract from PubMed ==
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| - | Recently, we extended the anti-adhesive concept showing that potent FimH antagonists can block the attachment of adherent-invasive E. coli (AIEC) colonizing the intestinal mucosa of patients with Crohn's disease (CD). In this work, we designed a small library of analogs of heptylmannoside (HM), a previously identified nanomolar FimH inhibitor, but displaying poor in vivo anti-adhesive effects. The anomeric oxygen atom was replaced by a sulfur or a methylene group to prevent hydrolysis by intestinal glycosidases, and chemical groups were attached at the end of the alkyl tail. Importantly, a lead compound was shown to reduce AIEC levels in the feces, colonic and ileal mucosa after oral administration in a transgenic mouse model of CD. The compound showed a preferable low bioavailability suggesting the possibility of setting up an innovative antiadhesive therapy for CD patients in which AIEC play a key role, with the water-soluble and non-cytotoxic FimH, antagonists developed here.
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| - | The anti-adhesive strategy in Crohn's disease: orally active mannosides to decolonize pathogenic Escherichia coli from the gut.,Dorta DA, Sivignon A, Chalopin T, Dumych T, Roos G, Bilyy R, Deniaud D, Krammer EM, De Ruyck J, Lensink M, Bouckaert J, Barnich N, Gouin SG Chembiochem. 2016 Mar 4. doi: 10.1002/cbic.201600018. PMID:26946458<ref>PMID:26946458</ref>
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| - | </div>
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| - | <div class="pdbe-citations 5ab1" style="background-color:#fffaf0;"></div>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Escherichia coli]]
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| - | [[Category: Bouckaert, J]]
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| - | [[Category: Ruyck, J de]]
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| - | [[Category: Bacterial adhesin]]
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| - | [[Category: Cell adhesion]]
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| - | [[Category: Type 1 fimbriae]]
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| - | [[Category: Urinary tract infection]]
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| - | [[Category: Variable immunoglobulin fold]]
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