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5i94

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==Crystal structure of human glutaminase C in complex with the inhibitor UPGL-00019==
==Crystal structure of human glutaminase C in complex with the inhibitor UPGL-00019==
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<StructureSection load='5i94' size='340' side='right' caption='[[5i94]], [[Resolution|resolution]] 2.98&Aring;' scene=''>
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<StructureSection load='5i94' size='340' side='right'caption='[[5i94]], [[Resolution|resolution]] 2.98&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5i94]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I94 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5i94]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5I94 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=69V:2-PHENYL-N-{5-[4-({5-[(PHENYLACETYL)AMINO]-1,3,4-THIADIAZOL-2-YL}OXY)PIPERIDIN-1-YL]-1,3,4-THIADIAZOL-2-YL}ACETAMIDE'>69V</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.983&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fi2|5fi2]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=69V:2-PHENYL-N-{5-[4-({5-[(PHENYLACETYL)AMINO]-1,3,4-THIADIAZOL-2-YL}OXY)PIPERIDIN-1-YL]-1,3,4-THIADIAZOL-2-YL}ACETAMIDE'>69V</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutaminase Glutaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.2 3.5.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5i94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i94 OCA], [https://pdbe.org/5i94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5i94 RCSB], [https://www.ebi.ac.uk/pdbsum/5i94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5i94 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i94 OCA], [http://pdbe.org/5i94 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i94 RCSB], [http://www.ebi.ac.uk/pdbsum/5i94 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GLSK_HUMAN GLSK_HUMAN]] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity.
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[https://www.uniprot.org/uniprot/GLSK_HUMAN GLSK_HUMAN] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5i94" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5i94" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Glutaminase 3D structures|Glutaminase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Glutaminase]]
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[[Category: Homo sapiens]]
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[[Category: Cerione, R]]
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[[Category: Large Structures]]
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[[Category: Huang, Q]]
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[[Category: Cerione R]]
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[[Category: Glutaminase c]]
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[[Category: Huang Q]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Inhibitor]]
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Current revision

Crystal structure of human glutaminase C in complex with the inhibitor UPGL-00019

PDB ID 5i94

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