5a0w

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==THE CRYSTAL STRUCTURE OF I-DMOI E117A IN COMPLEX WITH ITS TARGET DNA AND IN THE PRESENCE OF 2MM MN==
==THE CRYSTAL STRUCTURE OF I-DMOI E117A IN COMPLEX WITH ITS TARGET DNA AND IN THE PRESENCE OF 2MM MN==
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<StructureSection load='5a0w' size='340' side='right' caption='[[5a0w]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='5a0w' size='340' side='right'caption='[[5a0w]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5a0w]] is a 9 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A0W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A0W FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5a0w]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Desulfurococcus_mucosus Desulfurococcus mucosus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A0W FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a0m|5a0m]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a0w OCA], [http://pdbe.org/5a0w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a0w RCSB], [http://www.ebi.ac.uk/pdbsum/5a0w PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a0w OCA], [https://pdbe.org/5a0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a0w RCSB], [https://www.ebi.ac.uk/pdbsum/5a0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a0w ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DMO1_DESMO DMO1_DESMO]] Endonuclease involved in intron homing. Recognizes a recognizes up to 20 bp of DNA in the 23S rRNA gene intron. It has a slow turnover rate and cuts the coding strand with a slight preference over the non-coding strand.
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[https://www.uniprot.org/uniprot/DMO1_DESMO DMO1_DESMO] Endonuclease involved in intron homing. Recognizes a recognizes up to 20 bp of DNA in the 23S rRNA gene intron. It has a slow turnover rate and cuts the coding strand with a slight preference over the non-coding strand.
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==See Also==
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*[[Endonuclease 3D structures|Endonuclease 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Abramo, M D]]
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[[Category: Desulfurococcus mucosus]]
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[[Category: Besker, N]]
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[[Category: Large Structures]]
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[[Category: Molina, R]]
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[[Category: Synthetic construct]]
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[[Category: Montoya, G]]
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[[Category: Besker N]]
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[[Category: Prieto, J]]
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[[Category: D'Abramo M]]
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[[Category: Gene targeting]]
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[[Category: Molina R]]
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[[Category: Genetic]]
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[[Category: Montoya G]]
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[[Category: Homing endonuclease]]
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[[Category: Prieto J]]
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[[Category: Hydrolase-dna complex]]
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[[Category: Protein-dna interaction]]
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THE CRYSTAL STRUCTURE OF I-DMOI E117A IN COMPLEX WITH ITS TARGET DNA AND IN THE PRESENCE OF 2MM MN

PDB ID 5a0w

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