NK cell receptor
From Proteopedia
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| - | + | <StructureSection load='1kcg' size='350' side='right' caption='Human NK cell receptor NKG2D (grey and green) complex with class I MHC-like ligand ULBP3 (pink) and glutathione (PDB entry [[1kcg]])' scene=''> | |
== Function == | == Function == | ||
'''Natural killer (NK) cell receptors''' are located on the innate immune system NK cells. The receptors are differentiated into those activating effector function and those inhibiting it. The receptors induce apoptosis upon binding ligands which indicate infection<ref>PMID:9597134</ref>. | '''Natural killer (NK) cell receptors''' are located on the innate immune system NK cells. The receptors are differentiated into those activating effector function and those inhibiting it. The receptors induce apoptosis upon binding ligands which indicate infection<ref>PMID:9597134</ref>. | ||
| - | *NKG2D is expressed in NK cells, cytotoxic T cells and T cell subsets.<br /> | + | *'''NKG2D''' is expressed in NK cells, cytotoxic T cells and T cell subsets.<br /> |
*'''NKP''' are CD122(+) NK cell precursors.<br /> | *'''NKP''' are CD122(+) NK cell precursors.<br /> | ||
*'''2B4''' (CD244) are expressed on all NK cells, T cell subset, monocytes and basophils<ref>PMID:19499526</ref>. | *'''2B4''' (CD244) are expressed on all NK cells, T cell subset, monocytes and basophils<ref>PMID:19499526</ref>. | ||
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== Relevance == | == Relevance == | ||
| - | NKG2D is associated with response to cellular distress and infection<ref>PMID:14523385</ref>. | + | NKG2D is associated with response to cellular distress and infection<ref>PMID:14523385</ref>. |
| + | </StructureSection> | ||
==3D structures of NK cell receptor== | ==3D structures of NK cell receptor== | ||
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*NKG2D | *NKG2D | ||
| - | **[[1hq8]] – mNKG2D extracellular domain – mouse<br /> | ||
**[[1mpu]] – hNKG2D extracellular domain – human<br /> | **[[1mpu]] – hNKG2D extracellular domain – human<br /> | ||
| - | **[[1hyr]] – hNKG2D extracellular domain + class I MHC-like ligand MICA <br /> | + | **[[1hyr]], [[7fi5]], [[7fi6]], [[7fi7]], [[7fi8]], [[7fi9]] – hNKG2D extracellular domain + class I MHC-like ligand MICA <br /> |
**[[1kcg]] – hNKG2D extracellular domain + class I MHC-like ligand ULBP3<br /> | **[[1kcg]] – hNKG2D extracellular domain + class I MHC-like ligand ULBP3<br /> | ||
| + | **[[4s0u]] – hNKG2D extracellular domain + retinoic acid early transcript 1L protein <br /> | ||
**[[4pp8]] – mNKG2D extracellular domain + retinoic acid early-inducible protein 1β<br /> | **[[4pp8]] – mNKG2D extracellular domain + retinoic acid early-inducible protein 1β<br /> | ||
**[[4pdc]] – hNKG2D extracellular domain + cowpox virus protein<br /> | **[[4pdc]] – hNKG2D extracellular domain + cowpox virus protein<br /> | ||
**[[3bdw]] – hNKG2D extracellular domain + CD94<br /> | **[[3bdw]] – hNKG2D extracellular domain + CD94<br /> | ||
**[[3bdw]], [[3cii]] – hNKG2D extracellular domain + CD94 + MHC class I antigen E + β-2-microglobulin + HLA G antigen<br /> | **[[3bdw]], [[3cii]] – hNKG2D extracellular domain + CD94 + MHC class I antigen E + β-2-microglobulin + HLA G antigen<br /> | ||
| + | **[[8ea5]], [[8ea6]], [[8ea7]], [[8ea8]], [[8ea9]], [[8eaa]], [[8eab]] – hNKG2D extracellular domain + inhibitor<br /> | ||
| + | **[[1hq8]] – mNKG2D extracellular domain – mouse<br /> | ||
| - | * | + | *NKp |
| - | **[[1hkf]] – | + | **[[6yjp]] – hNKp30 IG domain 19-130 + hNKp30 ligand<br /> |
| - | **[[1oll]], [[1p6f]] – | + | **[[1hkf]] – hNKp44 IG domain <br /> |
| + | **[[1oll]], [[1p6f]] – hNKp46 extracellular domain 25-212<br /> | ||
*2B4 | *2B4 | ||
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*'''Inhibitory NK cell receptors''' | *'''Inhibitory NK cell receptors''' | ||
| - | *KIR | + | *KIR or killer cell immunoglobulin-like receptor |
| + | |||
| + | **[[3wyr]] – hKIR2dl4 extracellular domain <br /> | ||
| + | **[[3h8n]] – hKIR2ds4 extracellular domain <br /> | ||
| + | **[[3wuw]], [[5t70]], [[5t6z]], [[5b39]], [[5b38]], [[3vh8]], [[6v3j]], [[7duu]], [[7k80]] – hKIR3dl1 extracellular domain + MHC class I antigen B + β-2-microglobulin + IG κ chain C region<br /> | ||
| + | **[[6pag]] – hKIR3dl3 extracellular domain + MHC class I antigen B + β-2-microglobulin + peptide<br /> | ||
| + | **[[6pa1]] – hKIR2dl2 extracellular domain + MHC class I antigen B + β-2-microglobulin + peptide<br /> | ||
| + | **[[4n8v]] – hKIR2ds2 extracellular domain + MHC class I antigen B + β-2-microglobulin + peptide<br /> | ||
| + | |||
| + | *KLRG1 | ||
| + | |||
| + | **[[3fft]] – hKLRG1 + cadherin<br /> | ||
| - | **[[3vh8]] – hKIR extracellular domain + MHC class I antigen B + β-2-microglobulin + IG κ chain C region<br /> | ||
| - | **[[3wuw]] – hKIR extracellular domain + MHC class I antigen B + β-2-microglobulin + peptide<br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D structures of NK cell receptor
Updated on 20-July-2023
References
- ↑ Lanier LL. NK cell receptors. Annu Rev Immunol. 1998;16:359-93. PMID:9597134 doi:http://dx.doi.org/10.1146/annurev.immunol.16.1.359
- ↑ Mathew SO, Rao KK, Kim JR, Bambard ND, Mathew PA. Functional role of human NK cell receptor 2B4 (CD244) isoforms. Eur J Immunol. 2009 Jun;39(6):1632-41. doi: 10.1002/eji.200838733. PMID:19499526 doi:http://dx.doi.org/10.1002/eji.200838733
- ↑ Kane KP, Lavender KJ, Ma BJ. Ly-49 receptors and their functions. Crit Rev Immunol. 2004;24(5):321-48. PMID:15663362
- ↑ Norman PJ, Carrington CV, Byng M, Maxwell LD, Curran MD, Stephens HA, Chandanayingyong D, Verity DH, Hameed K, Ramdath DD, Vaughan RW. Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations. Genes Immun. 2002 Apr;3(2):86-95. PMID:11960306 doi:http://dx.doi.org/10.1038/sj.gene.6363836
- ↑ Raulet DH. Roles of the NKG2D immunoreceptor and its ligands. Nat Rev Immunol. 2003 Oct;3(10):781-90. PMID:14523385 doi:http://dx.doi.org/10.1038/nri1199
