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5fxy

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==Structure of the human RBBP4:MTA1(464-546) complex==
==Structure of the human RBBP4:MTA1(464-546) complex==
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<StructureSection load='5fxy' size='340' side='right' caption='[[5fxy]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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<StructureSection load='5fxy' size='340' side='right'caption='[[5fxy]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fxy]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FXY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fxy]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FXY FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fxy OCA], [http://pdbe.org/5fxy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fxy RCSB], [http://www.ebi.ac.uk/pdbsum/5fxy PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fxy OCA], [https://pdbe.org/5fxy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fxy RCSB], [https://www.ebi.ac.uk/pdbsum/5fxy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fxy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RBBP4_HUMAN RBBP4_HUMAN]] Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.<ref>PMID:10866654</ref> [[http://www.uniprot.org/uniprot/MTA1_HUMAN MTA1_HUMAN]] May be involved in the regulation of gene expression by covalent modification of histone proteins. Isoform Long is a corepressor of estrogen receptor (ER). Isoform Short binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER.
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[https://www.uniprot.org/uniprot/RBBP4_HUMAN RBBP4_HUMAN] Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.<ref>PMID:10866654</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5fxy" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5fxy" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Retinoblastoma-binding protein 3D structures|Retinoblastoma-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fairall, L]]
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[[Category: Homo sapiens]]
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[[Category: Millard, C J]]
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[[Category: Large Structures]]
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[[Category: Schwabe, J W.R]]
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[[Category: Fairall L]]
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[[Category: Varma, N]]
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[[Category: Millard CJ]]
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[[Category: Transcription]]
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[[Category: Schwabe JWR]]
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[[Category: Transcription repression complex metastasis associated complex mta1 rbbp4 rbbp7 histone binding protein]]
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[[Category: Varma N]]

Current revision

Structure of the human RBBP4:MTA1(464-546) complex

PDB ID 5fxy

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