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5fi1

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==Crystal Structure of the P-Rex1 DH/PH tandem in complex with Cdc42==
==Crystal Structure of the P-Rex1 DH/PH tandem in complex with Cdc42==
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<StructureSection load='5fi1' size='340' side='right' caption='[[5fi1]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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<StructureSection load='5fi1' size='340' side='right'caption='[[5fi1]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fi1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FI1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fi1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FI1 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5d27|5d27]], [[5d3v|5d3v]], [[5d3w|5d3w]], [[5d3x|5d3x]], [[5d3y|5d3y]], [[5fi0|5fi0]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.203&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fi1 OCA], [http://pdbe.org/5fi1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fi1 RCSB], [http://www.ebi.ac.uk/pdbsum/5fi1 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fi1 OCA], [https://pdbe.org/5fi1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fi1 RCSB], [https://www.ebi.ac.uk/pdbsum/5fi1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fi1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PREX1_HUMAN PREX1_HUMAN]] Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. [[http://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>
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[https://www.uniprot.org/uniprot/PREX1_HUMAN PREX1_HUMAN] Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5fi1" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5fi1" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cash, J N]]
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[[Category: Homo sapiens]]
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[[Category: Tesmer, J J.G]]
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[[Category: Large Structures]]
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[[Category: Dbl homology domain]]
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[[Category: Cash JN]]
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[[Category: Gtpase]]
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[[Category: Tesmer JJG]]
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[[Category: Pleckstrin homology domain]]
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[[Category: Protein binding]]
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[[Category: Rhogef]]
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[[Category: Signaling protein]]
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Current revision

Crystal Structure of the P-Rex1 DH/PH tandem in complex with Cdc42

PDB ID 5fi1

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