This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5b5v
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5b5v is ON HOLD Authors: KIM, S.-Y., Tachioka, Y., Mori, T., Hakoshima, T. Description: Structure of full-length MOB1b [[Category: Unreleased Struc...) |
|||
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of full-length MOB1b== | |
| - | + | <StructureSection load='5b5v' size='340' side='right'caption='[[5b5v]], [[Resolution|resolution]] 2.19Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5b5v]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5B5V FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.193Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b5v OCA], [https://pdbe.org/5b5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b5v RCSB], [https://www.ebi.ac.uk/pdbsum/5b5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b5v ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Mori | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/MOB1B_MOUSE MOB1B_MOUSE] Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L (By similarity). |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Hakoshima T]] | ||
| + | [[Category: KIM S-Y]] | ||
| + | [[Category: Mori T]] | ||
| + | [[Category: Tachioka Y]] | ||
Current revision
Structure of full-length MOB1b
| |||||||||||
