5b5v
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of full-length MOB1b== | |
| - | + | <StructureSection load='5b5v' size='340' side='right'caption='[[5b5v]], [[Resolution|resolution]] 2.19Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5b5v]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5B5V FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.193Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b5v OCA], [https://pdbe.org/5b5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b5v RCSB], [https://www.ebi.ac.uk/pdbsum/5b5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b5v ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Mori | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/MOB1B_MOUSE MOB1B_MOUSE] Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L (By similarity). |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Hakoshima T]] | ||
| + | [[Category: KIM S-Y]] | ||
| + | [[Category: Mori T]] | ||
| + | [[Category: Tachioka Y]] | ||
Current revision
Structure of full-length MOB1b
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