5jvx
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==X-ray structure of the adduct formed in the reaction between thaumatin and a gold carbene compound== | |
| + | <StructureSection load='5jvx' size='340' side='right'caption='[[5jvx]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5jvx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thaumatococcus_daniellii Thaumatococcus daniellii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JVX FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6O0:(1-BUTYL-3-METHYL-1,3-DIHYDRO-2H-IMIDAZOL-2-YLIDENE)(CHLORO)GOLD'>6O0</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jvx OCA], [https://pdbe.org/5jvx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jvx RCSB], [https://www.ebi.ac.uk/pdbsum/5jvx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jvx ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/THM1_THADA THM1_THADA] Taste-modifying protein; intensely sweet-tasting. It is 100000 times sweeter than sucrose on a molar basis. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The X-ray structure of the adduct formed in the reaction between the gold N-heterocyclic carbene compound Au(NHC)Cl (with NHC = 1-butyl-3-methyl-imidazole-2-ylidene) and the model protein thaumatin is reported here. The structure reveals binding of Au(NHC)+ fragments to distinct protein sites. Notably, binding of the gold compound occurs at lysine side chains and at the N-terminal tail; the metal binds the protein after releasing Cl- ligand, but retaining NHC fragment. | ||
| - | + | First Crystal Structure for a Gold Carbene-Protein Adduct.,Ferraro G, Gabbiani C, Merlino A Bioconjug Chem. 2016 Jul 6. PMID:27364343<ref>PMID:27364343</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Ferraro | + | <div class="pdbe-citations 5jvx" style="background-color:#fffaf0;"></div> |
| - | [[Category: Merlino | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Thaumatococcus daniellii]] | ||
| + | [[Category: Ferraro G]] | ||
| + | [[Category: Merlino A]] | ||
Current revision
X-ray structure of the adduct formed in the reaction between thaumatin and a gold carbene compound
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