5jyh
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution Structure of Hge36: Scorpine-like Peptide from Hadrurus Gertschi== | |
| + | <StructureSection load='5jyh' size='340' side='right'caption='[[5jyh]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5jyh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hadrurus_gertschi Hadrurus gertschi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JYH FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyh OCA], [https://pdbe.org/5jyh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jyh RCSB], [https://www.ebi.ac.uk/pdbsum/5jyh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyh ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KBX3_HOFGE KBX3_HOFGE] Has antibacterial activity against B.subtilis, but not against S.aureus. Also has hemolytic and cytolytic activities. Since cell lysis occurs at the tested concentrations, observation of activity on potassium channels is impossible.<ref>PMID:18030427</ref> Blocks Kv1.1/KCNA1 (IC(50)=185 nM) potassium channels. Shows a weak hemolytic activity.<ref>PMID:18030427</ref> <ref>PMID:27314815</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Scorpine-like peptides are two domain peptides found in different scorpion venoms displaying various antimicrobial, cytolytic, and potassium channel-blocking activities. The relative contribution of each domain to their different activities remains to be elucidated. Here, we report the recombinant production, solution structure, and antiparasitic activity of Hge36, first identified as a naturally occurring truncated form of a Scorpine-like peptide from the venom of Hoffmannihadrurus gertschi. We also show that removing the first four residues from Hge36 renders a molecule with enhanced potassium channel-blocking and antiparasitic activities. Our results are important to rationalize the structure-function relationships of a pharmacologically versatile molecular scaffold. | ||
| - | + | Solution structure and antiparasitic activity of scorpine-like peptides from Hoffmannihadrurus gertschi.,Flores-Solis D, Toledano Y, Rodriguez-Lima O, Cano-Sanchez P, Ramirez-Cordero BE, Landa A, Rodriguez de la Vega RC, Del Rio-Portilla F FEBS Lett. 2016 Jun 17. doi: 10.1002/1873-3468.12255. PMID:27314815<ref>PMID:27314815</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5jyh" style="background-color:#fffaf0;"></div> |
| - | [[Category: Flores-Solis | + | == References == |
| - | [[Category: Del Rio-Portilla | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Hadrurus gertschi]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Flores-Solis D]] | ||
| + | [[Category: Rodriguez De La Vega R]] | ||
| + | [[Category: Del Rio-Portilla F]] | ||
Current revision
Solution Structure of Hge36: Scorpine-like Peptide from Hadrurus Gertschi
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