5k11

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'''Unreleased structure'''
 
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The entry 5k11 is ON HOLD
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==Cryo-EM structure of isocitrate dehydrogenase (IDH1) in inhibitor-bound state==
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<SX load='5k11' size='340' side='right' viewer='molstar' caption='[[5k11]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5k11]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K11 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k11 OCA], [https://pdbe.org/5k11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k11 RCSB], [https://www.ebi.ac.uk/pdbsum/5k11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k11 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IDHC_HUMAN IDHC_HUMAN] Defects in IDH1 are involved in the development of glioma (GLM) [MIM:[https://omim.org/entry/137800 137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Mutations affecting Arg-132 are tissue-specific, and suggest that this residue plays a unique role in the development of high-grade gliomas. Mutations of Arg-132 to Cys, His, Leu or Ser abolish magnesium binding and abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate. Elevated levels of R(-)-2-hydroxyglutarate are correlated with an elevated risk of malignant brain tumors.
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== Function ==
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[https://www.uniprot.org/uniprot/IDHC_HUMAN IDHC_HUMAN]
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Authors: Merk, A., Bartesaghi, A., Banerjee, S., Falconieri, V., Rao, P., Earl, L., Milne, J., Subramaniam, S.
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==See Also==
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*[[Isocitrate dehydrogenase 3D structures|Isocitrate dehydrogenase 3D structures]]
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Description: Cryo-EM structure of isocitrate dehydrogenase (IDH1)
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__TOC__
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[[Category: Unreleased Structures]]
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</SX>
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[[Category: Milne, J]]
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[[Category: Homo sapiens]]
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[[Category: Merk, A]]
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[[Category: Large Structures]]
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[[Category: Falconieri, V]]
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[[Category: Banerjee S]]
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[[Category: Earl, L]]
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[[Category: Bartesaghi A]]
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[[Category: Banerjee, S]]
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[[Category: Earl L]]
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[[Category: Bartesaghi, A]]
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[[Category: Falconieri V]]
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[[Category: Rao, P]]
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[[Category: Merk A]]
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[[Category: Subramaniam, S]]
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[[Category: Milne J]]
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[[Category: Rao P]]
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[[Category: Subramaniam S]]

Current revision

Cryo-EM structure of isocitrate dehydrogenase (IDH1) in inhibitor-bound state

5k11, resolution 3.80Å

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