5k4f
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5k4f is ON HOLD until Paper Publication Authors: Zhao, Y., Madden, D.R. Description: CAL PDZ mutant C319A with a peptide [[Category: Unreleased Str...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==CAL PDZ mutant C319A with a peptide== | |
| - | + | <StructureSection load='5k4f' size='340' side='right'caption='[[5k4f]], [[Resolution|resolution]] 1.36Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5k4f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_papillomavirus_type_18 Human papillomavirus type 18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K4F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K4F FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.36Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k4f OCA], [https://pdbe.org/5k4f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k4f RCSB], [https://www.ebi.ac.uk/pdbsum/5k4f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k4f ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Madden | + | == Disease == |
| + | [https://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Human papillomavirus type 18]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Madden DR]] | ||
| + | [[Category: Zhao Y]] | ||
Current revision
CAL PDZ mutant C319A with a peptide
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