5k4z
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==M. thermoresistible IMPDH in complex with IMP and Compound 6== | |
| + | <StructureSection load='5k4z' size='340' side='right'caption='[[5k4z]], [[Resolution|resolution]] 1.64Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5k4z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_thermoresistibile Mycolicibacterium thermoresistibile]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K4Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K4Z FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6Q8:~{N}-(4-FLUOROPHENYL)-4-(2~{H}-INDAZOL-6-YLSULFAMOYL)-3,5-DIMETHYL-1~{H}-PYRROLE-2-CARBOXAMIDE'>6Q8</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k4z OCA], [https://pdbe.org/5k4z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k4z RCSB], [https://www.ebi.ac.uk/pdbsum/5k4z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k4z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/G7CNL4_MYCT3 G7CNL4_MYCT3] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964] | ||
| - | + | ==See Also== | |
| - | + | *[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Blundell | + | [[Category: Mycolicibacterium thermoresistibile]] |
| - | [[Category: | + | [[Category: Ascher DB]] |
| + | [[Category: Blundell TL]] | ||
| + | [[Category: Pacitto A]] | ||
Current revision
M. thermoresistible IMPDH in complex with IMP and Compound 6
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