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1ivx

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[[Image:1ivx.gif|left|200px]]
 
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{{Structure
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==Crystal structure of copper amine oxidase from Arthrobacter globiformis: Holo form generated by biogenesis in crystal.==
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|PDB= 1ivx |SIZE=350|CAPTION= <scene name='initialview01'>1ivx</scene>, resolution 2.2&Aring;
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<StructureSection load='1ivx' size='340' side='right'caption='[[1ivx]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=TPQ:5-(2-CARBOXY-2-AMINOETHYL)-2-HYDROXY-1,4-BENZOQUINONE'>TPQ</scene>
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<table><tr><td colspan='2'>[[1ivx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arthrobacter_globiformis Arthrobacter globiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IVX FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Amine_oxidase_(copper-containing) Amine oxidase (copper-containing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.6 1.4.3.6] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=TPQ:5-(2-CARBOXY-2-AMINOETHYL)-2-HYDROXY-1,4-BENZOQUINONE'>TPQ</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ivx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ivx OCA], [https://pdbe.org/1ivx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ivx RCSB], [https://www.ebi.ac.uk/pdbsum/1ivx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ivx ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1av4|1AV4]], [[1avk|1AVK]], [[1avl|1AVL]], [[1iqx|1IQX]], [[1iqy|1IQY]], [[1iu7|1IU7]], [[1ivu|1IVU]], [[1ivv|1IVV]], [[1ivw|1IVW]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ivx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ivx OCA], [http://www.ebi.ac.uk/pdbsum/1ivx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ivx RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/PAOX_ARTGO PAOX_ARTGO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iv/1ivx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ivx ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The quinone cofactor TPQ in copper amine oxidase is generated by posttranslational modification of an active site tyrosine residue. Using X-ray crystallography, we have probed the copper-dependent autooxidation process of TPQ in the enzyme from Arthrobacter globiformis. Apo enzyme crystals were anaerobically soaked with copper; the structure determined from this crystal provides a view of the initial state: the unmodified tyrosine coordinated to the bound copper. Exposure of the copper-bound crystals to oxygen led to the formation of freeze-trapped intermediates; structural analyses indicate that these intermediates contain dihydroxyphenylalanine quinone and trihydroxyphenylalanine. These are the first visualized intermediates during TPQ biogenesis in copper amine oxidase.
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'''Crystal structure of copper amine oxidase from Arthrobacter globiformis: Holo form generated by biogenesis in crystal.'''
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X-ray snapshots of quinone cofactor biogenesis in bacterial copper amine oxidase.,Kim M, Okajima T, Kishishita S, Yoshimura M, Kawamori A, Tanizawa K, Yamaguchi H Nat Struct Biol. 2002 Aug;9(8):591-6. PMID:12134140<ref>PMID:12134140</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1ivx" style="background-color:#fffaf0;"></div>
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==Overview==
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==See Also==
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The quinone cofactor TPQ in copper amine oxidase is generated by posttranslational modification of an active site tyrosine residue. Using X-ray crystallography, we have probed the copper-dependent autooxidation process of TPQ in the enzyme from Arthrobacter globiformis. Apo enzyme crystals were anaerobically soaked with copper; the structure determined from this crystal provides a view of the initial state: the unmodified tyrosine coordinated to the bound copper. Exposure of the copper-bound crystals to oxygen led to the formation of freeze-trapped intermediates; structural analyses indicate that these intermediates contain dihydroxyphenylalanine quinone and trihydroxyphenylalanine. These are the first visualized intermediates during TPQ biogenesis in copper amine oxidase.
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*[[Copper amine oxidase 3D structures|Copper amine oxidase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1IVX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Arthrobacter_globiformis Arthrobacter globiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IVX OCA].
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__TOC__
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</StructureSection>
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==Reference==
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X-ray snapshots of quinone cofactor biogenesis in bacterial copper amine oxidase., Kim M, Okajima T, Kishishita S, Yoshimura M, Kawamori A, Tanizawa K, Yamaguchi H, Nat Struct Biol. 2002 Aug;9(8):591-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12134140 12134140]
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[[Category: Amine oxidase (copper-containing)]]
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[[Category: Arthrobacter globiformis]]
[[Category: Arthrobacter globiformis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Kawamori, A.]]
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[[Category: Kawamori A]]
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[[Category: Kim, M.]]
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[[Category: Kim M]]
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[[Category: Kishishita, S.]]
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[[Category: Kishishita S]]
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[[Category: Okajima, T.]]
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[[Category: Okajima T]]
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[[Category: Tanizawa, K.]]
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[[Category: Tanizawa K]]
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[[Category: Yamaguchi, H.]]
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[[Category: Yamaguchi H]]
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[[Category: Yoshimura, M.]]
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[[Category: Yoshimura M]]
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[[Category: amine oxidase]]
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[[Category: biogenesis]]
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[[Category: copper]]
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[[Category: freeze-trapp]]
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[[Category: intermediate]]
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[[Category: oxidoreductase]]
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[[Category: quinone cofactor]]
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[[Category: tpq]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:25:21 2008''
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Current revision

Crystal structure of copper amine oxidase from Arthrobacter globiformis: Holo form generated by biogenesis in crystal.

PDB ID 1ivx

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