5fh7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:51, 19 July 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal structure of the fifth bromodomain of human PB1 in complex with compound 18==
==Crystal structure of the fifth bromodomain of human PB1 in complex with compound 18==
-
<StructureSection load='5fh7' size='340' side='right' caption='[[5fh7]], [[Resolution|resolution]] 1.47&Aring;' scene=''>
+
<StructureSection load='5fh7' size='340' side='right'caption='[[5fh7]], [[Resolution|resolution]] 1.47&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5fh7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FH7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FH7 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5fh7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FH7 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5XL:6-CHLORANYL-3-[(DIMETHYLAMINO)METHYL]-4~{H}-PYRROLO[1,2-A]QUINAZOLIN-5-ONE'>5XL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.47&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fh7 OCA], [http://pdbe.org/5fh7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fh7 RCSB], [http://www.ebi.ac.uk/pdbsum/5fh7 PDBsum]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5XL:6-CHLORANYL-3-[(DIMETHYLAMINO)METHYL]-4~{H}-PYRROLO[1,2-A]QUINAZOLIN-5-ONE'>5XL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fh7 OCA], [https://pdbe.org/5fh7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fh7 RCSB], [https://www.ebi.ac.uk/pdbsum/5fh7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fh7 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[http://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>
+
[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>
+
[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 24: Line 25:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Arrowsmith, C H]]
+
[[Category: Homo sapiens]]
-
[[Category: Bountra, C]]
+
[[Category: Large Structures]]
-
[[Category: Brennan, P E]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Delft, F von]]
+
[[Category: Bountra C]]
-
[[Category: Edwards, A M]]
+
[[Category: Brennan PE]]
-
[[Category: Fedorov, O]]
+
[[Category: Edwards AM]]
-
[[Category: Knapp, S]]
+
[[Category: Fedorov O]]
-
[[Category: Krojer, T]]
+
[[Category: Knapp S]]
-
[[Category: Ley, S V]]
+
[[Category: Krojer T]]
-
[[Category: Picaud, S]]
+
[[Category: Ley SV]]
-
[[Category: Siejka, P]]
+
[[Category: Picaud S]]
-
[[Category: Sorrell, F J]]
+
[[Category: Siejka P]]
-
[[Category: Sutherell, C L]]
+
[[Category: Sorrell FJ]]
-
[[Category: Tallant, C]]
+
[[Category: Sutherell CL]]
-
[[Category: Brg1-associated factor 180]]
+
[[Category: Tallant C]]
-
[[Category: Chromatin remodeling]]
+
[[Category: Von Delft F]]
-
[[Category: Pbrm1]]
+
-
[[Category: Transcription]]
+

Current revision

Crystal structure of the fifth bromodomain of human PB1 in complex with compound 18

PDB ID 5fh7

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5fh7"
Personal tools