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5ixi

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==Structure of human JAK1 FERM/SH2 in complex with IFNLR1/IL10RA chimera==
==Structure of human JAK1 FERM/SH2 in complex with IFNLR1/IL10RA chimera==
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<StructureSection load='5ixi' size='340' side='right' caption='[[5ixi]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
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<StructureSection load='5ixi' size='340' side='right'caption='[[5ixi]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ixi]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IXI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IXI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ixi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IXI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IXI FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ixd|5ixd]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ixi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ixi OCA], [https://pdbe.org/5ixi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ixi RCSB], [https://www.ebi.ac.uk/pdbsum/5ixi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ixi ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ixi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ixi OCA], [http://pdbe.org/5ixi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ixi RCSB], [http://www.ebi.ac.uk/pdbsum/5ixi PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN]] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. [[http://www.uniprot.org/uniprot/INLR1_HUMAN INLR1_HUMAN]] The IFNLR1/IL10RB dimer is a receptor for IFNL1, IFNL2 and IFNL3. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.<ref>PMID:12521379</ref> <ref>PMID:12469119</ref> <ref>PMID:12483210</ref>
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[https://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5ixi" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ixi" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Janus kinase 3D structures|Janus kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Non-specific protein-tyrosine kinase]]
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[[Category: Homo sapiens]]
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[[Category: Ferrao, R]]
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[[Category: Large Structures]]
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[[Category: Lupardus, P J]]
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[[Category: Ferrao R]]
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[[Category: Wallweber, H J.A]]
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[[Category: Lupardus PJ]]
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[[Category: Cytokine]]
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[[Category: Wallweber HJA]]
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[[Category: Ifnlr1]]
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[[Category: Il10]]
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[[Category: Il10ra]]
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[[Category: Interferon]]
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[[Category: Jak kinase]]
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[[Category: Jak1]]
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Current revision

Structure of human JAK1 FERM/SH2 in complex with IFNLR1/IL10RA chimera

PDB ID 5ixi

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