5cdw
From Proteopedia
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==Crystal Structure Analysis of a mutant Grb2 SH2 domain (W121G) with a pYVNV peptide== | ==Crystal Structure Analysis of a mutant Grb2 SH2 domain (W121G) with a pYVNV peptide== | ||
- | <StructureSection load='5cdw' size='340' side='right' caption='[[5cdw]], [[Resolution|resolution]] 2.60Å' scene=''> | + | <StructureSection load='5cdw' size='340' side='right'caption='[[5cdw]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[5cdw]] is a 32 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CDW OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5cdw]] is a 32 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CDW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CDW FirstGlance]. <br> |
- | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.602Å</td></tr> |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr> |
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cdw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cdw OCA], [https://pdbe.org/5cdw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cdw RCSB], [https://www.ebi.ac.uk/pdbsum/5cdw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cdw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
- | [ | + | [https://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5cdw" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5cdw" style="background-color:#fffaf0;"></div> | ||
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+ | ==See Also== | ||
+ | *[[Growth factor receptor-bound proteins 3D structures|Growth factor receptor-bound proteins 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: | + | [[Category: Homo sapiens]] |
- | [[Category: | + | [[Category: Large Structures]] |
- | [[Category: | + | [[Category: Geibel S]] |
- | [[Category: | + | [[Category: Kay C]] |
- | [[Category: | + | [[Category: Kunze M]] |
- | [[Category: | + | [[Category: Papaioannou D]] |
- | [[Category: | + | [[Category: Waksman G]] |
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Current revision
Crystal Structure Analysis of a mutant Grb2 SH2 domain (W121G) with a pYVNV peptide
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Categories: Homo sapiens | Large Structures | Geibel S | Kay C | Kunze M | Papaioannou D | Waksman G