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5a2p

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==THE COMPLEX STRUCTURE OF PDZ DOMAINS IN SYNTENIN-1 WITH 4L PEPTIDE==
==THE COMPLEX STRUCTURE OF PDZ DOMAINS IN SYNTENIN-1 WITH 4L PEPTIDE==
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<StructureSection load='5a2p' size='340' side='right' caption='[[5a2p]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='5a2p' size='340' side='right'caption='[[5a2p]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5a2p]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A2P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A2P FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5a2p]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A2P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A2P FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a2p OCA], [http://pdbe.org/5a2p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a2p RCSB], [http://www.ebi.ac.uk/pdbsum/5a2p PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.496&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a2p OCA], [https://pdbe.org/5a2p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a2p RCSB], [https://www.ebi.ac.uk/pdbsum/5a2p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a2p ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SDCB1_RAT SDCB1_RAT]] Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.[UniProtKB:O00560] [[http://www.uniprot.org/uniprot/SDC4_RAT SDC4_RAT]] Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.[UniProtKB:P31431]
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[https://www.uniprot.org/uniprot/SDCB1_RAT SDCB1_RAT] Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.[UniProtKB:O00560]
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==See Also==
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*[[3D structures of syntenin|3D structures of syntenin]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cho, H S]]
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[[Category: Large Structures]]
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[[Category: Lee, W]]
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[[Category: Rattus norvegicus]]
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[[Category: Yoo, J H]]
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[[Category: Cho HS]]
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[[Category: Yun, J H]]
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[[Category: Lee W]]
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[[Category: Cell adhesion]]
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[[Category: Yoo JH]]
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[[Category: Pdz domain]]
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[[Category: Yun JH]]
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[[Category: Signaling protein]]
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[[Category: Syndecan-4]]
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[[Category: Syntenin-1]]
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Current revision

THE COMPLEX STRUCTURE OF PDZ DOMAINS IN SYNTENIN-1 WITH 4L PEPTIDE

PDB ID 5a2p

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