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Nucleoporin

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{{STRUCTURE_1xip| PDB=1xip | SIZE=300| SCENE=Nucleoporin/Cv/1 |right|CAPTION=yeast Nucleoporin NUP159, [[1xip]] }}
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<StructureSection load='' size='350' side='right' caption='Yeast nucleoporin NUP159 N-terminal domain (PDB entry [[1xip]])' scene='Nucleoporin/Cv/1'>
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== Function ==
[[Nucleoporin|Nucleoporins]] (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD), N-terminal domain (NTD) and C-terminal domain (CTD)<ref>PMID:9159086</ref>. <br />
[[Nucleoporin|Nucleoporins]] (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD), N-terminal domain (NTD) and C-terminal domain (CTD)<ref>PMID:9159086</ref>. <br />
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*NUP1P is a yeast nucleoprotein required for nuclear protein import, mRNA export and maintenance of nuclear architecture<ref>PMID:8045927</ref>. <br />
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*'''NUP1P''' is a yeast nucleoprotein required for nuclear protein import, mRNA export and maintenance of nuclear architecture<ref>PMID:8045927</ref>. <br />
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*NUP2P is a yeast nucleoprotein required for bidirectional transport of importin α<ref>PMID:11046143</ref>. <br />
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*'''NUP2P''' is a yeast nucleoprotein required for bidirectional transport of importin α<ref>PMID:11046143</ref>. <br />
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*'''NUP Gle1''' is a yeast and human nucleoprotein required mRNA export. <br />
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== Disease ==
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NUP98 and NUP214 gene translocation is associated with myeloid and lymphoid malignancies. NUP88 is over expressed in ovarian tumors. NUP214 is the functional receptor of adenovirus 2 nucleocapsids<ref>PMID:14693424</ref>.
== 3D Structures of Nucleoporin ==
== 3D Structures of Nucleoporin ==
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[[Nucleoporin 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*NUP2
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**[[3n7c]] – NUP2 RANBD – ''Ashbya gossypii''<br />
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**[[2c1t]] – yNUP2 NTD +importrin alpha subunit - yeast<br />
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*NUP35
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**[[1wwh]] – mNUP35 MPPN domain - mouse<br />
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*NUP37
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**[[4fhl]] – fyNUP37 – fission yeast<br />
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**[[4fhm]], [[4fhn]], [[4gq2]] - fyNUP37 + NUP120<br />
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*NUP43
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**[[4i79]] – hNUP43 + polypeptide<br />
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*NUP50
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**[[2ec1]] – hNUP50 RANBD - human<br />
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**[[2c1m]] – mNUP50 NTD +importin <br />
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**[[3tj3]] - hNUP50 NTD+importin<br />
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*NUP53
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**[[3p3d]] - NUP53 RRM domain - ''Pischia guillermondii''<br />
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**[[4lir]] – hNUP53 residues 151-266<br />
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*NUP54
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**[[3t97]] – rNUP54 + NUP62 - rat<br />
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**[[4j3h]] – rNUP54 (mutant)<br />
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**[[3t98]] – rNUP54 + rNUP58/45 <br />
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**[[4jo7]], [[4jo9]] – hNUP54 + hNUP58/45 <br />
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*NUP58
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**[[2osz]] – rNUP58/45 <br />
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**[[4jq5]] – hNUP58/45 <br />
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*NUP82
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**[[3pbp]] – yNUP82 NTD + NUP116 CTD + NUP159 tail<br />
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**[[3tkn]] - yNUP82 NTD + NUP98 + NUP159 tail<br />
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*NUP84
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**[[3jro]], [[3iko]] – yNUP84+NUP145+protein Sec13<br />
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**[[4xmm]] - yNUP84+NUP85+NUP120+NUP145+protein Seh1 + antibody<br />
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**[[4xmn]] - yNUP84+NUP85+NUP120+NUP145 + antibody<br />
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*NUP85
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**[[3f3f]], [[3f3g]], [[3f3p]], [[3ewe]] – yNUP85+Seh1<br />
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*NUP98
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**[[3mmy]] – hNUP98 fragment+mRNA export factor <br />
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**[[2q5x]], [[2q5y]] – hNUP98 CTD<br />
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**[[1ko6]] – hNUP98 CTD<br />
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*NUP100
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**[[3nf5]] – NUP100 CTD – ''Candida glabrata''<br />
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*NUP107
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**[[3i4r]], [[3cqc]], [[3cqg]] – hNUP107+NUP133<br />
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*NUP116
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**[[2aiv]] – yNUP116 CTD - NMR<br />
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*NUP120
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**[[3f7f]], [[3h7n]], [[3hxr]] – yNUP120<br />
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*NUP133
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**[[1xks]], [[4q9t]] – hNUP133 NTD<br />
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**[[3kfo]] – yNUP133 CTD <br />
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*NUP145
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**[[3bg0]], [[3bg1]] – hNUP145+Sec13-related protein<br />
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**[[3kep]], [[3kes]] – yNUP145 autoproteolytic domain<br />
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**[[3jrp]] - yNUP145+protein Sec13<br />
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*NUP153
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**[[3gj3]], [[3gj4]], [[3gj5]], [[3gj6]], [[3gj7]], [[3gj8]], [[3ch5]] – hNUP153+RAN<br />
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**[[2ebq]], [[2ebr]], [[2ebv]], [[2gqe]] - hNUP153 RANBD – NMR<br />
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**[[2k0c]] – rNUP153 RANBD – NMR<br />
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*NUP157
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**[[4mhc]] – hNUP157 NTD<br />
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*NUP159
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**[[1xip]] – yNUP159 NTD<br />
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**[[3rrm]] – yNUP159 residues 2-387 + NUP Gle1 + IP6 + ADP<br />
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*NUP170
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**[[3i5p]], [[3i5q]] – yNUP170<br />
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*NUP192
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**[[4ifq]] – yNUP192<br />
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*NUP214
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**[[3fmo]], [[3fmp]], [[3fhc]] – hNUP214+dead-box helicase<br />
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**[[2oit]] – hNUP214 NTD<br />
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*NUP358
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**[[1z5s]] – hNUP358 IR1 domain+ubiquitin-conjugating enzyme+SMT3C+RAN CTD<br />
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**[[1xke]] - hNUP358 RANBD - NMR<br />
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*NUP1P
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**[[2bpt]] – yNUP1P+importin β subunit<br />
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*NUP2P
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**[[1un0]] – yNUP2P NTD+importrin α subunit<br />
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*NUP-NSP1
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**[[1o6o]] – yNUP-NSP1 residues 497-608+importrin β subunit<br />
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*NUP-CDC31
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**[[2doq]], [[2gv5]] – yNUP-CDC31+SFI1P<br />
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**[[3fwb]], [[3fwc]] - yNUP-CDC31+SAC3<br />
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*NUP Gle1
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**[[3peu]], [[3pev]], [[3rrn]]– yNUP-Gle1 + ATP-dependent RNA helicase Dbp5 (mutant) +IP6
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**[[2rfo]], [[2qx5]] – yNic96<br />
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**[[1gyb]] – NUP+yNTF2<br />
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}}
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== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Yeast nucleoporin NUP159 N-terminal domain (PDB entry 1xip)

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References

  1. ↑ Doye V, Hurt E. From nucleoporins to nuclear pore complexes. Curr Opin Cell Biol. 1997 Jun;9(3):401-11. PMID:9159086
  2. ↑ Belanger KD, Kenna MA, Wei S, Davis LI. Genetic and physical interactions between Srp1p and nuclear pore complex proteins Nup1p and Nup2p. J Cell Biol. 1994 Aug;126(3):619-30. PMID:8045927
  3. ↑ Solsbacher J, Maurer P, Vogel F, Schlenstedt G. Nup2p, a yeast nucleoporin, functions in bidirectional transport of importin alpha. Mol Cell Biol. 2000 Nov;20(22):8468-79. PMID:11046143
  4. ↑ Cronshaw JM, Matunis MJ. The nuclear pore complex: disease associations and functional correlations. Trends Endocrinol Metab. 2004 Jan-Feb;15(1):34-9. PMID:14693424

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