Formate dehydrogenase
From Proteopedia
(Difference between revisions)
| (10 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | <StructureSection load=' | + | <StructureSection load='' size='350' side='right' scene='49/491980/Cv/1' caption='NAD-dependent formate dehydrogenase dimer complex with cofactor NAD and sulfate, [[2nad]]'> |
'''Formate dehydrogenase''' (FDH) catalyzes the reversible two-electron oxidation of formate to bicarbonate. The product electron is donated to either [[NAD]]+ in NAD-dependent FDH or to Mo-dependent FDH where the electron is donated to a Fe<sub>4</sub>S<sub>4</sub> center and then to cytochrome. The '''Mo-dependent FDH-H''' from ''E. coli'' contains SelCys, Mo, molybdopterin guanosine dinucleotide (MGD) cofactor and Fe<sub>4</sub>S<sub>4</sub><ref>PMID:2094290</ref>. | '''Formate dehydrogenase''' (FDH) catalyzes the reversible two-electron oxidation of formate to bicarbonate. The product electron is donated to either [[NAD]]+ in NAD-dependent FDH or to Mo-dependent FDH where the electron is donated to a Fe<sub>4</sub>S<sub>4</sub> center and then to cytochrome. The '''Mo-dependent FDH-H''' from ''E. coli'' contains SelCys, Mo, molybdopterin guanosine dinucleotide (MGD) cofactor and Fe<sub>4</sub>S<sub>4</sub><ref>PMID:2094290</ref>. | ||
| + | *<scene name='49/491980/Cv/8'>NAD binding site</scene> in NAD-dependent formate dehydrogenase ([[2nad]]). Water molecules shown as red spheres. | ||
| + | *<scene name='49/491980/Cv/9'>Azide ion binding site</scene>. | ||
==3D structure of formate dehydrogenase== | ==3D structure of formate dehydrogenase== | ||
| + | [[Formate dehydrogenase 3D structures]] | ||
| - | + | </StructureSection> | |
| - | + | ||
| - | *NAD-dependent FDH | ||
| - | |||
| - | **[[2nac]], [[2go1]] – PsFDH – ''Pseudomonas''<BR /> | ||
| - | **[[2fss]] – CbFDH – ''Candida boidinii''<BR /> | ||
| - | **[[2j6i]] – CbFDH C terminal (mutant) <BR /> | ||
| - | **[[3fn4]] - MoFDH – ''Moraxella''<BR /> | ||
| - | **[[3naq]], [[3jtm]] – ArFDH – ''Arabidopsis thaliana''<BR /> | ||
| - | **[[2nad]] – PsFDH + NAD<BR /> | ||
| - | **[[2gug]] – PsFDH + formate<BR /> | ||
| - | **[[2gsd]] – MoFDH + NAD + N3<BR /> | ||
| - | **[[3n7u]] - ArFDH + NAD + N3<BR /> | ||
| - | **[[3wr5]] – FDH + NAD – ''Thiobacillus''<br /> | ||
| - | |||
| - | *Mo-dependent FDH | ||
| - | |||
| - | **[[1aa6]], [[1fdo]], [[2iv2]] – EcFDH-H + Fe4S4 + MGD – ''Escherichia coli''<BR /> | ||
| - | **[[1fdi]] - EcFDH-H + Fe4S4 + NO2 + MGD<BR /> | ||
| - | **[[1kqf]] - EcFDH-N + Fe4S4 + protoporphyrin + MGD<BR /> | ||
| - | **[[1kqg]] - EcFDH-N + Fe4S4 + protoporphyrin + heptyl-oxy-quinolinol + MGD<BR /> | ||
| - | **[[1h0h]] - FDH + Fe4S4 +MGD – ''Desulfovibrio gigas'' | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
