Obscurin

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{{STRUCTURE_2yz8| PDB=2yz8 | SIZE=400| SCENE= |right|CAPTION=Human obscurin of 32th IG-like domain residues 3184-3273 [[2yz8]] }}
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<StructureSection load='2yz8' size='350' side='right' caption='Human obscurin of 32th IG-like domain residues 3184-3273 (PDB entry [[2yz8]])' scene=''>
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== Function ==
== Function ==
'''Obscurin''' (Obs) or '''KIAA1556''' is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains.
'''Obscurin''' (Obs) or '''KIAA1556''' is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains.
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== Disease ==
== Disease ==
Mutations of Obs are found in hypertrophy cardiomyopathy<ref>PMID:17716621</ref>.
Mutations of Obs are found in hypertrophy cardiomyopathy<ref>PMID:17716621</ref>.
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</StructureSection>
==3D structures of obscurin==
==3D structures of obscurin==
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**[[2e7b]] - hObs 6th Ig domain residues 8-97 – human - NMR<BR />
**[[2e7b]] - hObs 6th Ig domain residues 8-97 – human - NMR<BR />
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**[[2dm7]] - hObs 14th Ig domain residues 1157-1251 – NMR<br />
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**[[2eo1]] - hObs Ig domain residues 69-163 – NMR<br />
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**[[7r68]] - hObs 12th Ig domain residues 1071-1162 – NMR<br />
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**[[2dm7]], [[7r67]] - hObs 13th Ig domain residues 1161-1254 – NMR<br />
**[[2gqh]] - hObs 15th Ig domain residues 1253-1346 – NMR<br />
**[[2gqh]] - hObs 15th Ig domain residues 1253-1346 – NMR<br />
**[[2eny]] - hObs Ig domain residues 2735-2825 – NMR<BR />
**[[2eny]] - hObs Ig domain residues 2735-2825 – NMR<BR />
**[[2edf]] - hObs 2nd Ig domain residues 2826-2915 – NMR<BR />
**[[2edf]] - hObs 2nd Ig domain residues 2826-2915 – NMR<BR />
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**[[2dku]] - hObs Ig domain residues 2915-3004 – NMR<br />
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**[[2dku]] - hObs 3rd Ig domain residues 2915-3004 – NMR<br />
**[[2cr6]] - hObs Ig domain residues 2998-3100 – NMR<BR />
**[[2cr6]] - hObs Ig domain residues 2998-3100 – NMR<BR />
**[[2yz8]] - hObs 32nd Ig domain residues 3184-3273 <br />
**[[2yz8]] - hObs 32nd Ig domain residues 3184-3273 <br />
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**[[2edq]] - hObs Ig domain residues 3713-3806 – NMR<BR />
**[[2edq]] - hObs Ig domain residues 3713-3806 – NMR<BR />
**[[2edl]] - hObs Ig domain residues 3801-3897 – NMR<BR />
**[[2edl]] - hObs Ig domain residues 3801-3897 – NMR<BR />
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**[[6mg9]] - hObs 57th Ig domain residues 4247-4338 – NMR<br />
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**[[2mwc]], [[4rsv]] - hObs 58th Ig domain residues 4337-4429 – NMR<br />
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**[[5tzm]] - hObs 59th Ig domain residues 4946-5036 <br />
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**[[2n56]] - hObs 59th Ig domain residues 4430-4524 – NMR<br />
**[[1v1c]] - hObs SH3 domain residues 5601-5668 – NMR<BR />
**[[1v1c]] - hObs SH3 domain residues 5601-5668 – NMR<BR />
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**[[8ak2]] - DmObs kinase domain residues 3186-3480 – ''Drosophila melanogaster''<br />
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**[[8ak3]] - DmObs kinase domain + ADP<br />
*Obscurin-like protein 1
*Obscurin-like protein 1
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**[[5fm5]] - hObsL 3rd Ig domain residues 251-339 + myomesin-1<br />
**[[2e6q]] - hObsL Ig domain residues 615-713 – NMR<BR />
**[[2e6q]] - hObsL Ig domain residues 615-713 – NMR<BR />
**[[2e6p]] - hObsL Ig domain residues 714-804 – NMR<BR />
**[[2e6p]] - hObsL Ig domain residues 714-804 – NMR<BR />
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**[[3knb]], [[2wp3]], [[2wwm]], [[4c4k]] – hObs N terminal residues 1-105 + titin M10 domain <br />
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**[[2lvc]] - hObsL 6th Ig domain residues 805-892 – NMR<br />
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**[[4uow]] - hObs residues 26829-26925+ titin M10 domain<br />
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**[[2lu7]] - hObsL 11th Ig domain residues 1277-1357 – NMR<br />
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**[[2wwk]] – hObs N terminal residues 1-105 (mutant) + titin M10 domain<br />
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**[[3knb]], [[2wp3]], [[2wwm]], [[4c4k]] – hObsL N terminal residues 1-105 + titin M10 domain <br />
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**[[2wwk]] – hObsL N terminal residues (mutant) + titin M10 domain<br />
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**[[4uow]] - hObsL residues 26829-26925 + titin M10 domain<br />
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}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human obscurin of 32th IG-like domain residues 3184-3273 (PDB entry 2yz8)

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3D structures of obscurin

17-August-2023

References

  1. ↑ Kontrogianni-Konstantopoulos A, Catino DH, Strong JC, Sutter S, Borisov AB, Pumplin DW, Russell MW, Bloch RJ. Obscurin modulates the assembly and organization of sarcomeres and the sarcoplasmic reticulum. FASEB J. 2006 Oct;20(12):2102-11. PMID:17012262 doi:10.1096/fj.06-5761com
  2. ↑ Arimura T, Matsumoto Y, Okazaki O, Hayashi T, Takahashi M, Inagaki N, Hinohara K, Ashizawa N, Yano K, Kimura A. Structural analysis of obscurin gene in hypertrophic cardiomyopathy. Biochem Biophys Res Commun. 2007 Oct 19;362(2):281-7. Epub 2007 Aug 13. PMID:17716621 doi:10.1016/j.bbrc.2007.07.183

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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