This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Oligopeptide-binding protein
From Proteopedia
(Difference between revisions)
| (12 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | + | <StructureSection load='' size='350' side='right' caption='Oligopeptide-binding protein (grey) complex with peptide bradykinin (cyan) and Cl- ion (green) (PDB entry [[3drg]])' scene='48/488461/Cv/1'> | |
| - | + | == Function == | |
'''Oligopeptide-binding protein''' (Opp) is a component of the | '''Oligopeptide-binding protein''' (Opp) is a component of the | ||
oligopeptide permease which is an ABC-type transporter system. Opp binds polypeptides up to pentapeptide in length with high affinity. Opp is required for sporulation and competence. Opp carries oligopeptides to the membrane-associated oligopeptide permease<ref>PMID:14618258</ref>. | oligopeptide permease which is an ABC-type transporter system. Opp binds polypeptides up to pentapeptide in length with high affinity. Opp is required for sporulation and competence. Opp carries oligopeptides to the membrane-associated oligopeptide permease<ref>PMID:14618258</ref>. | ||
| + | |||
| + | == Structural highlights == | ||
| + | The bradykinin peptide is nestled between the 2 domains of Opp<ref>PMID:19300437</ref>. <scene name='48/488461/Cv/6'>Bradykinin peptide binding site</scene>. | ||
| + | *<scene name='48/488461/Cv/7'>Cl coordination site</scene>. Water molecule is shown as red sphere. | ||
| + | </StructureSection> | ||
==3D structures of oligopeptide-binding protein== | ==3D structures of oligopeptide-binding protein== | ||
| - | + | See [[ABC transporter]] | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | **[[1ola]], [[1olc]] – StOpp + tetrapeptide<br /> | ||
| - | **[[2olb]], [[1jet]], [[1jeu]], [[1jev]], [[1b1h]], [[1b3f]], [[1b3g]], [[1b3l]], [[1b32]], [[1b40]], [[1b46]], [[1b4z]], [[1b5i]], [[1b5j]], [[1b51]], [[1b52]], [[1b58]], [[1b9j]], [[1b0h]], [[1b05]], [[1qka]], [[1qkb]] - StOpp + tripeptide<br /> | ||
| - | **[[2rkm]] - StOpp + dipeptide<br /> | ||
| - | **[[1b4h]] - StOpp + Lys-DAB-Lys<br /> | ||
| - | **[[1b5h]] - StOpp + Lys-DPP-Lys<br /> | ||
| - | **[[1b6h]] - StOpp + Lys-NVA-Lys<br /> | ||
| - | **[[1b7h]] - StOpp + Lys-NLE-Lys<br /> | ||
| - | **[[1b2h]] - StOpp + Lys-ORN-Lys<br /> | ||
| - | **[[1b1h]] - StOpp + Lys-HPE-Lys<br /> | ||
| - | **[[1b3h]] - StOBpp+ Lys-ALC-Lys<br /> | ||
| - | **[[2z23]] - Opp + tripeptide – ''Yersinia pestis''<br /> | ||
| - | **[[3drf]], [[3dri]] - LlOpp + octapeptide<br /> | ||
| - | **[[3rya]], [[3ryb]] - LlOpp + nonapeptide<br /> | ||
| - | **[[3drg]] - LlOpp + bradykinin peptide<br /> | ||
| - | **[[3drh]] - LlOpp + hexapeptide<br /> | ||
| - | **[[3drj]] - LlOpp + PTH-related peptide<br /> | ||
| - | **[[3drk]] - LlOpp + neuropeptide S<br /> | ||
| - | **[[2wok]] - ScOpp + bradykinin peptide <br /> | ||
| - | **[[2wop]] - ScOpp + arginine<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
3D structures of oligopeptide-binding protein
See ABC transporter
References
- ↑ Monnet V. Bacterial oligopeptide-binding proteins. Cell Mol Life Sci. 2003 Oct;60(10):2100-14. PMID:14618258 doi:http://dx.doi.org/10.1007/s00018-003-3054-3
- ↑ Berntsson RP, Doeven MK, Fusetti F, Duurkens RH, Sengupta D, Marrink SJ, Thunnissen AM, Poolman B, Slotboom DJ. The structural basis for peptide selection by the transport receptor OppA. EMBO J. 2009 Mar 19. PMID:19300437 doi:emboj200965
