Penicillopepsin
From Proteopedia
(Difference between revisions)
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | + | <StructureSection load='1ppm' size='400' side='right' scene='49/493723/Cv/1' caption='Glycosylated penicillopepsin complex with peptide analog and sulfate, [[1ppm]]' pspeed='8'> | |
| + | |||
== Function == | == Function == | ||
'''Penicillopepsin''' (PP) is a proteinase with a broad spectrum of substrates. PP prefers hydrophobic residues at P1 and P1’ sites. PP is a member of the aspartic proteinase family. Its extended binding site cleft can bind at least 7 amino acids<ref>PMID:1172664</ref>. | '''Penicillopepsin''' (PP) is a proteinase with a broad spectrum of substrates. PP prefers hydrophobic residues at P1 and P1’ sites. PP is a member of the aspartic proteinase family. Its extended binding site cleft can bind at least 7 amino acids<ref>PMID:1172664</ref>. | ||
| Line 6: | Line 7: | ||
PP causes clotting in milk and activates trypsinogen. | PP causes clotting in milk and activates trypsinogen. | ||
| + | == Structural highlights == | ||
| + | *<scene name='49/493723/Cv/3'>Binding site</scene>. | ||
| + | *<scene name='49/493723/Cv/4'>Binding site cleft</scene>. | ||
| + | </StructureSection> | ||
==3D structures of penicillopepsin== | ==3D structures of penicillopepsin== | ||
| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[3app]] – PjPP – ''Penicillium janthinellum''<br /> | [[3app]] – PjPP – ''Penicillium janthinellum''<br /> | ||
Current revision
| |||||||||||
3D structures of penicillopepsin
Updated on 18-July-2024
3app – PjPP – Penicillium janthinellum
1ppl, 1ppm, 1ppk – PjPP + peptide analog
1apt, 1apu, 1apv, 1apw - PjPP + pepstatin analog
2wea, 2web, 2wec, 2wed, 1bxo, 1bxq - PjPP + peptidyl inhibitor
