4ryr

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==Crystal structure of BcTSPO, type 2 at 1.7 Angstrom with DMSO==
==Crystal structure of BcTSPO, type 2 at 1.7 Angstrom with DMSO==
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<StructureSection load='4ryr' size='340' side='right' caption='[[4ryr]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='4ryr' size='340' side='right'caption='[[4ryr]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ryr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RYR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RYR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ryr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_cereus_ATCC_14579 Bacillus cereus ATCC 14579]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RYR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RYR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MPG:[(Z)-OCTADEC-9-ENYL]+(2R)-2,3-BIS(OXIDANYL)PROPANOATE'>MPG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.704&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ryi|4ryi]], [[4ryj|4ryj]], [[4rym|4rym]], [[4ryn|4ryn]], [[4ryo|4ryo]], [[4ryq|4ryq]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MPG:[(Z)-OCTADEC-9-ENYL]+(2R)-2,3-BIS(OXIDANYL)PROPANOATE'>MPG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ryr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ryr OCA], [http://pdbe.org/4ryr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ryr RCSB], [http://www.ebi.ac.uk/pdbsum/4ryr PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ryr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ryr OCA], [https://pdbe.org/4ryr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ryr RCSB], [https://www.ebi.ac.uk/pdbsum/4ryr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ryr ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TSPO_BACCR TSPO_BACCR] Binds tetrapyrroles and promotes the photooxidative degradation of protoporphyrin IX (PubMed:25635100). Can bind the benzodiazepine receptor agonist PK-11195 (in vitro); this interferes with photooxidative tetrapyrrole degradation (PubMed:25635100). May play a role in the transmembrane transport of tetrapyrroles and similar compounds (By similarity).[UniProtKB:Q9RFC8]<ref>PMID:25635100</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Guo, Y]]
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[[Category: Bacillus cereus ATCC 14579]]
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[[Category: Hendrickson, W A]]
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[[Category: Large Structures]]
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[[Category: Liu, Q]]
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[[Category: Guo Y]]
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[[Category: NYCOMPS, New York Consortium on Membrane Protein Structure]]
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[[Category: Hendrickson WA]]
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[[Category: Membrane protein]]
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[[Category: Liu Q]]
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[[Category: New york consortium on membrane protein structure]]
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[[Category: Nycomp]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Psi-biology]]
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[[Category: Receptor]]
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[[Category: Structural genomic]]
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Current revision

Crystal structure of BcTSPO, type 2 at 1.7 Angstrom with DMSO

PDB ID 4ryr

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