This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5l7r
From Proteopedia
(Difference between revisions)
m (Protected "5l7r" [edit=sysop:move=sysop]) |
|||
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of BvGH123== | |
| + | <StructureSection load='5l7r' size='340' side='right'caption='[[5l7r]], [[Resolution|resolution]] 1.85Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5l7r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Phocaeicola_vulgatus_ATCC_8482 Phocaeicola vulgatus ATCC 8482]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L7R FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l7r OCA], [https://pdbe.org/5l7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l7r RCSB], [https://www.ebi.ac.uk/pdbsum/5l7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l7r ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A6L2E5_PHOV8 A6L2E5_PHOV8] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Bacteroides vulgatus is a member of the human microbiota whose abundance is increased in patients with Crohn's disease. We show that a B. vulgatus glycoside hydrolase from the carbohydrate active enzyme family GH123, BvGH123, is an N-acetyl-beta-galactosaminidase that acts with retention of stereochemistry, and, through a 3-D structure in complex with Gal-thiazoline, provide evidence in support of a neighbouring group participation mechanism. | ||
| - | + | Structural and mechanistic insights into a Bacteroides vulgatus retaining N-acetyl-beta-galactosaminidase that uses neighbouring group participation.,Roth C, Petricevic M, John A, Goddard-Borger ED, Davies GJ, Williams SJ Chem Commun (Camb). 2016 Sep 25;52(74):11096-9. doi: 10.1039/c6cc04649e. Epub, 2016 Aug 22. PMID:27546776<ref>PMID:27546776</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5l7r" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Phocaeicola vulgatus ATCC 8482]] | ||
| + | [[Category: Davies GJ]] | ||
| + | [[Category: Goddard-Borger ED]] | ||
| + | [[Category: John A]] | ||
| + | [[Category: Petricevic M]] | ||
| + | [[Category: Roth C]] | ||
| + | [[Category: Williams SJ]] | ||
Current revision
Crystal structure of BvGH123
| |||||||||||
