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5f1o

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==human CD38 in complex with nanobody MU551==
==human CD38 in complex with nanobody MU551==
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<StructureSection load='5f1o' size='340' side='right' caption='[[5f1o]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='5f1o' size='340' side='right'caption='[[5f1o]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5f1o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F1O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F1O FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5f1o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F1O FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5f1k|5f1k]], [[5f21|5f21]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ADP-ribosyl_cyclase/cyclic_ADP-ribose_hydrolase ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.6 3.2.2.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f1o OCA], [https://pdbe.org/5f1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f1o RCSB], [https://www.ebi.ac.uk/pdbsum/5f1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f1o ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f1o OCA], [http://pdbe.org/5f1o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f1o RCSB], [http://www.ebi.ac.uk/pdbsum/5f1o PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
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[https://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase]]
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[[Category: Homo sapiens]]
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[[Category: Hao, Q]]
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[[Category: Lama glama]]
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[[Category: Zhang, H]]
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[[Category: Large Structures]]
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[[Category: Adp-ribosyl cyclase]]
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[[Category: Hao Q]]
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[[Category: Calcium signaling]]
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[[Category: Zhang H]]
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[[Category: Cd38]]
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[[Category: Cyclic adp-ribose]]
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[[Category: Hydrolase-immune system complex]]
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[[Category: Mu551]]
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[[Category: Nanobody]]
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[[Category: X-crystallography]]
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Current revision

human CD38 in complex with nanobody MU551

PDB ID 5f1o

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