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5ays

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==Crystal structure of SAUGI/HSV UDG complex==
==Crystal structure of SAUGI/HSV UDG complex==
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<StructureSection load='5ays' size='340' side='right' caption='[[5ays]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
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<StructureSection load='5ays' size='340' side='right'caption='[[5ays]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ays]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AYS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ays]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AYS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AYS FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ayr|5ayr]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uracil-DNA_glycosylase Uracil-DNA glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.27 3.2.2.27] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ays FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ays OCA], [https://pdbe.org/5ays PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ays RCSB], [https://www.ebi.ac.uk/pdbsum/5ays PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ays ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ays FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ays OCA], [http://pdbe.org/5ays PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ays RCSB], [http://www.ebi.ac.uk/pdbsum/5ays PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/UNG_HHV11 UNG_HHV11]] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosine. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly, in terminally differentiated neurons which lack DNA repair enzymes.<ref>PMID:7552746</ref> <ref>PMID:16306042</ref>
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[https://www.uniprot.org/uniprot/UNG_HHV11 UNG_HHV11] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosine. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly, in terminally differentiated neurons which lack DNA repair enzymes.<ref>PMID:7552746</ref> <ref>PMID:16306042</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5ays" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ays" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Uracil-DNA glycosylase]]
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[[Category: Human alphaherpesvirus 1 strain 17]]
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[[Category: Huang, M F]]
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[[Category: Large Structures]]
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[[Category: Ko, T P]]
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[[Category: Staphylococcus aureus]]
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[[Category: Wang, A H.J]]
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[[Category: Huang MF]]
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[[Category: Wang, H C]]
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[[Category: Ko TP]]
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[[Category: Dna mimic protein]]
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[[Category: Wang AHJ]]
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[[Category: Dna mimicking]]
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[[Category: Wang HC]]
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[[Category: Herpes simplex virus]]
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[[Category: Hydrolase inhibitor]]
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[[Category: Uracil-dna glycosylase]]
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[[Category: Uracil-dna glycosylase inhibitor]]
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Current revision

Crystal structure of SAUGI/HSV UDG complex

PDB ID 5ays

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