5iot

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==Flavin-dependent thymidylate synthase R174A variant in complex with FAD and dUMP==
==Flavin-dependent thymidylate synthase R174A variant in complex with FAD and dUMP==
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<StructureSection load='5iot' size='340' side='right' caption='[[5iot]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='5iot' size='340' side='right'caption='[[5iot]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5iot]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IOT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5iot]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IOT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IOT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ioq|5ioq]], [[5ior|5ior]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase_(FAD) Thymidylate synthase (FAD)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.148 2.1.1.148] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5iot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iot OCA], [https://pdbe.org/5iot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5iot RCSB], [https://www.ebi.ac.uk/pdbsum/5iot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5iot ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iot OCA], [http://pdbe.org/5iot PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iot RCSB], [http://www.ebi.ac.uk/pdbsum/5iot PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/THYX_THEMA THYX_THEMA]] Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate.
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[https://www.uniprot.org/uniprot/THYX_THEMA THYX_THEMA] Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5iot" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5iot" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bernard, S M]]
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[[Category: Large Structures]]
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[[Category: Smith, J L]]
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[[Category: Thermotoga maritima MSB8]]
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[[Category: Stull, F W]]
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[[Category: Bernard SM]]
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[[Category: Fad-dependent]]
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[[Category: Smith JL]]
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[[Category: Nucleotide biosynthesis]]
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[[Category: Stull FW]]
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[[Category: Reductive methylation]]
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[[Category: Transferase]]
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Current revision

Flavin-dependent thymidylate synthase R174A variant in complex with FAD and dUMP

PDB ID 5iot

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