5jer

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==Structure of Rotavirus NSP1 bound to IRF-3==
==Structure of Rotavirus NSP1 bound to IRF-3==
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<StructureSection load='5jer' size='340' side='right' caption='[[5jer]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
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<StructureSection load='5jer' size='340' side='right'caption='[[5jer]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5jer]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JER OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JER FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5jer]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rotavirus_A Rotavirus A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JER FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jej|5jej]], [[5jel|5jel]], [[5jek|5jek]], [[5jem|5jem]], [[5jeo|5jeo]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.913&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jer FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jer OCA], [http://pdbe.org/5jer PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jer RCSB], [http://www.ebi.ac.uk/pdbsum/5jer PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jer FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jer OCA], [https://pdbe.org/5jer PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jer RCSB], [https://www.ebi.ac.uk/pdbsum/5jer PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jer ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IRF3_HUMAN IRF3_HUMAN]] Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
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[https://www.uniprot.org/uniprot/NSP1_ROTS4 NSP1_ROTS4] Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7. Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities.[HAMAP-Rule:MF_04088]<ref>PMID:15741273</ref> <ref>PMID:17251580</ref> <ref>PMID:17301153</ref> <ref>PMID:27099313</ref> <ref>PMID:27302953</ref>
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==See Also==
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*[[Interferon regulatory factor|Interferon regulatory factor]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Li, P]]
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[[Category: Homo sapiens]]
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[[Category: Zhao, B]]
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[[Category: Large Structures]]
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[[Category: Immune system]]
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[[Category: Rotavirus A]]
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[[Category: Viral immunity]]
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[[Category: Li P]]
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[[Category: Zhao B]]

Current revision

Structure of Rotavirus NSP1 bound to IRF-3

PDB ID 5jer

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