5k9m
From Proteopedia
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==Crystal Structure of PriB Binary Complex with Product Diphosphate== | ==Crystal Structure of PriB Binary Complex with Product Diphosphate== | ||
| - | <StructureSection load='5k9m' size='340' side='right' caption='[[5k9m]], [[Resolution|resolution]] 1.50Å' scene=''> | + | <StructureSection load='5k9m' size='340' side='right'caption='[[5k9m]], [[Resolution|resolution]] 1.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5k9m]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K9M OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5k9m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_sp._RM-5-8 Streptomyces sp. RM-5-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K9M FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k9m OCA], [https://pdbe.org/5k9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k9m RCSB], [https://www.ebi.ac.uk/pdbsum/5k9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k9m ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A182DWE5_9ACTN A0A182DWE5_9ACTN] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | This study highlights the biochemical and structural characterization of the L-tryptophan C6 C-prenyltransferase (C-PT) PriB from Streptomyces sp. RM-5-8. PriB was found to be uniquely permissive to a diverse array of prenyl donors and acceptors including daptomycin. Two additional PTs also produced novel prenylated daptomycins with improved antibacterial activities over the parent drug. | ||
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| + | Structure and specificity of a permissive bacterial C-prenyltransferase.,Elshahawi SI, Cao H, Shaaban KA, Ponomareva LV, Subramanian T, Farman ML, Spielmann HP, Phillips GN Jr, Thorson JS, Singh S Nat Chem Biol. 2017 Feb 6. doi: 10.1038/nchembio.2285. PMID:28166207<ref>PMID:28166207</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5k9m" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Streptomyces sp. RM-5-8]] |
| - | [[Category: | + | [[Category: Benach J]] |
| - | + | [[Category: Cao H]] | |
| - | [[Category: | + | [[Category: Elshahawi S]] |
| - | [[Category: | + | [[Category: Koss JW]] |
| - | + | [[Category: Morisco LL]] | |
| - | + | [[Category: Phillips Jr GN]] | |
| - | [[Category: | + | [[Category: Thorson JS]] |
| - | [[Category: | + | [[Category: Wasserman SR]] |
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Current revision
Crystal Structure of PriB Binary Complex with Product Diphosphate
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