5jhn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:37, 6 March 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5jhn is ON HOLD until Paper Publication
+
==Structure of G9a SET-domain with Histone H3K9Ala mutant peptide and bound S-adenosylmethionine==
 +
<StructureSection load='5jhn' size='340' side='right'caption='[[5jhn]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[5jhn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JHN FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jhn OCA], [https://pdbe.org/5jhn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jhn RCSB], [https://www.ebi.ac.uk/pdbsum/5jhn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jhn ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/EHMT2_HUMAN EHMT2_HUMAN] Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.<ref>PMID:8457211</ref> <ref>PMID:11316813</ref> <ref>PMID:18438403</ref> <ref>PMID:20118233</ref> <ref>PMID:22387026</ref>
-
Authors: Jayaram, H., Bellon, S.F., Poy, F.
+
==See Also==
-
 
+
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
-
Description: Structure of G9a SET-domain with Histone H3K9Ala mutant peptide and bound S-adenosylmethionine
+
== References ==
-
[[Category: Unreleased Structures]]
+
<references/>
-
[[Category: Poy, F]]
+
__TOC__
-
[[Category: Jayaram, H]]
+
</StructureSection>
-
[[Category: Bellon, S.F]]
+
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Bellon SF]]
 +
[[Category: Jayaram H]]
 +
[[Category: Poy F]]

Current revision

Structure of G9a SET-domain with Histone H3K9Ala mutant peptide and bound S-adenosylmethionine

PDB ID 5jhn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5jhn"
Personal tools