4rpb

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==Crystal Structure of P Domain of Snow Mountain Norovirus==
==Crystal Structure of P Domain of Snow Mountain Norovirus==
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<StructureSection load='4rpb' size='340' side='right' caption='[[4rpb]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
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<StructureSection load='4rpb' size='340' side='right'caption='[[4rpb]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4rpb]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RPB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4rpb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_Hu/GII.2/KL109/1978/MYS Norovirus Hu/GII.2/KL109/1978/MYS]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RPB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.61&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rpb OCA], [http://pdbe.org/4rpb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rpb RCSB], [http://www.ebi.ac.uk/pdbsum/4rpb PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rpb OCA], [https://pdbe.org/4rpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rpb RCSB], [https://www.ebi.ac.uk/pdbsum/4rpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rpb ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/K7X601_9CALI K7X601_9CALI]
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Human norovirus interacts with the polymorphic human histo-blood group antigens (HBGAs), and this interaction is thought to be important for infection. The genogroup II genotype 4 (GII.4) noroviruses are the dominant cluster, evolve every other year, and are thought to modify their binding interactions with different HBGA types. Most human noroviruses bind HBGAs, while some strains were found to have minimal or no HBGA interactions. Here, we explain some possible structural constraints for several noroviruses that were found to bind poorly to HBGAs by using X-ray crystallography. We showed that one aspartic acid was flexible or positioned away from the fucose moiety of the HBGAs and this likely hindered binding, although other fucose-interacting residues were perfectly oriented. Interestingly, a neighboring loop also appeared to influence the loop hosting the aspartic acid. These new findings might explain why some human noroviruses bound HBGAs poorly, although further studies are required.
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Structural Constraints on Human Norovirus Binding to Histo-Blood Group Antigens.,Singh BK, Leuthold MM, Hansman GS mSphere. 2016 Mar 30;1(2). pii: e00049-16. doi: 10.1128/mSphere.00049-16., eCollection 2016 Mar-Apr. PMID:27303720<ref>PMID:27303720</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4rpb" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hansman, G S]]
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[[Category: Large Structures]]
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[[Category: Singh, B K]]
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[[Category: Norovirus Hu/GII 2/KL109/1978/MYS]]
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[[Category: Hbga]]
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[[Category: Hansman GS]]
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[[Category: Viral protein]]
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[[Category: Singh BK]]
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[[Category: Virus internalization]]
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[[Category: Virus surface]]
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Current revision

Crystal Structure of P Domain of Snow Mountain Norovirus

PDB ID 4rpb

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