1jgs

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:39, 7 February 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1jgs.jpg|left|200px]]
 
-
{{Structure
+
==Multiple Antibiotic Resistance Repressor, MarR==
-
|PDB= 1jgs |SIZE=350|CAPTION= <scene name='initialview01'>1jgs</scene>, resolution 2.3&Aring;
+
<StructureSection load='1jgs' size='340' side='right'caption='[[1jgs]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=SAL:2-HYDROXYBENZOIC+ACID'>SAL</scene>
+
<table><tr><td colspan='2'>[[1jgs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JGS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JGS FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAL:2-HYDROXYBENZOIC+ACID'>SAL</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jgs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jgs OCA], [https://pdbe.org/1jgs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jgs RCSB], [https://www.ebi.ac.uk/pdbsum/1jgs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jgs ProSAT]</span></td></tr>
-
|RELATEDENTRY=
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jgs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jgs OCA], [http://www.ebi.ac.uk/pdbsum/1jgs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jgs RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/MARR_ECOLI MARR_ECOLI] Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site.
-
 
+
== Evolutionary Conservation ==
-
'''Multiple Antibiotic Resistance Repressor, MarR'''
+
[[Image:Consurf_key_small.gif|200px|right]]
-
 
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
==Overview==
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/1jgs_consurf.spt"</scriptWhenChecked>
-
MarR is a regulator of multiple antibiotic resistance in Escherichia coli. It is the prototypical member of the MarR family of regulatory proteins found in bacteria and archaea that play important roles in the development of antibiotic resistance, a global health problem. Here we describe the crystal structure of the MarR protein, determined at a resolution of 2.3 A. This is the first reported crystal structure of a member of this newly-described protein family. The structure shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
1JGS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JGS OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jgs ConSurf].
-
 
+
<div style="clear:both"></div>
-
==Reference==
+
__TOC__
-
The crystal structure of MarR, a regulator of multiple antibiotic resistance, at 2.3 A resolution., Alekshun MN, Levy SB, Mealy TR, Seaton BA, Head JF, Nat Struct Biol. 2001 Aug;8(8):710-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11473263 11473263]
+
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Alekshun, M N.]]
+
[[Category: Alekshun MN]]
-
[[Category: Head, J F.]]
+
[[Category: Head JF]]
-
[[Category: Levy, S B.]]
+
[[Category: Levy SB]]
-
[[Category: Mealy, T R.]]
+
[[Category: Mealy TR]]
-
[[Category: Seaton, B A.]]
+
[[Category: Seaton BA]]
-
[[Category: antibiotic resistance]]
+
-
[[Category: dna-binding]]
+
-
[[Category: repressor]]
+
-
[[Category: transcription regulation]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:33:25 2008''
+

Current revision

Multiple Antibiotic Resistance Repressor, MarR

PDB ID 1jgs

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jgs"
Personal tools