Preprotein translocase
From Proteopedia
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== Function == | == Function == | ||
'''Preprotein translocase''' (PPT) is responsible for the recognition and membrane translocation of preproteins. PPT contains receptors and import motor<ref>PMID:9489663</ref>. The translocase pathway contains:<br /> | '''Preprotein translocase''' (PPT) is responsible for the recognition and membrane translocation of preproteins. PPT contains receptors and import motor<ref>PMID:9489663</ref>. The translocase pathway contains:<br /> | ||
| - | *'''SecB''' - a chaperone protein <br /> | + | *'''SecB''' - a chaperone protein<ref>PMID:9767586</ref> <br /> |
| - | *'''SecY, SecE, SecG''' an integral membrane complex<br /> | + | *'''SecY, SecE, SecG''' or '''Sec61''' an integral membrane complex<br /> |
*'''SecD, SecF''' - proteins promoting the release of the mature peptide into the periplasm<br /> | *'''SecD, SecF''' - proteins promoting the release of the mature peptide into the periplasm<br /> | ||
| - | *'''SecA''' - an ATPase unit.<br /> | + | *'''SecA''' - an ATPase unit<ref>PMID:10617931</ref>.<br /> |
For more details see [[SecA PBD motions]]. | For more details see [[SecA PBD motions]]. | ||
| - | </StructureSection> | ||
==3D structures of preprotein translocase== | ==3D structures of preprotein translocase== | ||
| - | + | [[Preprotein translocase 3D structures]] | |
| - | + | ||
| - | *Preprotein translocase SecY + SecE + SecB | ||
| - | |||
| - | **[[1rh5]], [[1rhz]] – MjPPT SecY + SecE + SecB – ''Methanocaldococcus jannaschii'' <br /> | ||
| - | |||
| - | *Preprotein translocase SecY + SecE + SecG | ||
| - | |||
| - | **[[2akh]], [[2aki]] – EcPPT SecY + SecE + SecG – ''Escherichia coli'' - CryoEM <br /> | ||
| - | **[[2yxq]], [[2yxr]] – MjPPT SecY + SecE + SecG <br /> | ||
| - | **[[3dkn]] – PPT SecY + SecE + SecG + RNA – dog - CryoEM <br /> | ||
| - | **[[3bo0]], [[3bo1]] – EcPPT SecY + SecE + SecG + 23S ribosomal RNA - CryoEM<br /> | ||
| - | **[[3kcr]], [[3j45]], [[3j46]] – EcPPT SecY + SecE + SecG + large ribosomal subunit - CryoEM<br /> | ||
| - | **[[1vvk]] – MjPPT SecY + SecE + SecG + large ribosomal subunit - CryoEM<br /> | ||
| - | |||
| - | *Preprotein translocase SecY + SecE | ||
| - | |||
| - | **[[3mp7]] – PPT SecY + SecE – ''Pyrococcus furiosus'' <br /> | ||
| - | **[[2zjs]] – TtPPT SecY + SecE + antibody – ''Thermus thermophilus''<br /> | ||
| - | **[[2zqp]] – TtPPT SecY + SecE <br /> | ||
| - | **[[3j01]] – EcPPT SecY + SecE + large ribosomal subunit - CryoEM<br /> | ||
| - | |||
| - | *Preprotein translocase SecY + SecE + SecG + SecA | ||
| - | |||
| - | **[[3din]] – TmPPT SecY + SecE + SecG + SecA – ''Thermotoga maritima''<br /> | ||
| - | **[[3dl8]] – PPT SecY + SecE + SecA + SecG – ''Aquifex aeolicus'' - CryoEM<br /> | ||
| - | |||
| - | *Preprotein translocase SecA | ||
| - | |||
| - | **[[1m6n]], [[1tf5]], [[2ibm]] – BsPPT SecA – ''Bacillus subtilis'' <br /> | ||
| - | **[[3iqm]], [[3iqy]] – BsPPT SecA (mutant)<br /> | ||
| - | **[[1tm6]] – EcPPT SecA C terminal - NMR<br /> | ||
| - | **[[2ipc]] – TtPPT SecA<br /> | ||
| - | **[[3jux]] – TmPPT SecA<br /> | ||
| - | **[[2fsf]] – EcPPT SecA<br /> | ||
| - | **[[2fsf]] – EcPPT SecA<br /> | ||
| - | **[[3bxz]] – EcPPT SecA dead motor domains (mutant)<br /> | ||
| - | **[[1nl3]] – MtPPT SecA – ''Mycobacterium tuberculosis''<br /> | ||
| - | |||
| - | *Preprotein translocase SecA complex | ||
| - | |||
| - | **[[1m74]], [[1tf2]] – BsPPT SecA + Mg + ADP <br /> | ||
| - | **[[1ozb]] – PPT SecA C terminal + SecB - ''Haemophilus influenzae''<br /> | ||
| - | **[[2fsh]] – EcPPT SecA + AMPPNP<br /> | ||
| - | **[[2fsi]] – EcPPT SecA + ADP<br /> | ||
| - | **[[2fsg]] – EcPPT SecA + ATP<br /> | ||
| - | **[[2vda]] – EcPPT SecA + maltoporin signal peptide - NMR<br /> | ||
| - | **[[3jv2]] – BsPPT SecA + peptide <br /> | ||
| - | **[[1nkt]] – MtPPT SecA + ADP<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | </StructureSection> | ||
| + | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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