1jig

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:39, 7 February 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1jig.jpg|left|200px]]
 
-
{{Structure
+
==Dlp-2 from Bacillus anthracis==
-
|PDB= 1jig |SIZE=350|CAPTION= <scene name='initialview01'>1jig</scene>, resolution 1.46&Aring;
+
<StructureSection load='1jig' size='340' side='right'caption='[[1jig]], [[Resolution|resolution]] 1.46&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>
+
<table><tr><td colspan='2'>[[1jig]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JIG FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.46&#8491;</td></tr>
-
|GENE= dlp-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jig OCA], [https://pdbe.org/1jig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jig RCSB], [https://www.ebi.ac.uk/pdbsum/1jig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jig ProSAT]</span></td></tr>
-
|RELATEDENTRY=
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jig OCA], [http://www.ebi.ac.uk/pdbsum/1jig PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jig RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/DPS1_BACAN DPS1_BACAN] Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton Fe(2+) ion (By similarity). It is capable of binding and sequestering Fe(2+) ion. Does not bind DNA.
-
 
+
== Evolutionary Conservation ==
-
'''Dlp-2 from Bacillus anthracis'''
+
[[Image:Consurf_key_small.gif|200px|right]]
-
 
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
==Overview==
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ji/1jig_consurf.spt"</scriptWhenChecked>
-
Bacillus anthracis is currently under intense investigation due to its primary importance as a human pathogen. Particularly important is the development of novel anti-anthrax vaccines, devoid of the current side effects. A novel class of immunogenic bacterial proteins consists of dodecamers homologous to the DNA-binding protein of Escherichia coli (Dps). Two Dps homologous genes are present in the B. anthracis genome. The crystal structures of these two proteins (Dlp-1 and Dlp-2) have been determined and are presented here. They are sphere-like proteins with an internal cavity. We also show that they act as ferritins and are thus involved in iron uptake and regulation, a fundamental function during bacterial growth.
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
1JIG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JIG OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jig ConSurf].
-
 
+
<div style="clear:both"></div>
-
==Reference==
+
__TOC__
-
Structure of two iron-binding proteins from Bacillus anthracis., Papinutto E, Dundon WG, Pitulis N, Battistutta R, Montecucco C, Zanotti G, J Biol Chem. 2002 Apr 26;277(17):15093-8. Epub 2002 Feb 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11836250 11836250]
+
</StructureSection>
[[Category: Bacillus anthracis]]
[[Category: Bacillus anthracis]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Battistutta, R.]]
+
[[Category: Battistutta R]]
-
[[Category: Dundon, W G.]]
+
[[Category: Dundon WG]]
-
[[Category: Montecucco, C.]]
+
[[Category: Montecucco C]]
-
[[Category: Papinutto, E.]]
+
[[Category: Papinutto E]]
-
[[Category: Pitulis, N.]]
+
[[Category: Pitulis N]]
-
[[Category: Zanotti, G.]]
+
[[Category: Zanotti G]]
-
[[Category: dodecamer]]
+
-
[[Category: four-helix bundle]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:34:09 2008''
+

Current revision

Dlp-2 from Bacillus anthracis

PDB ID 1jig

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jig"
Personal tools