5ctt

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==Crystal structure of human SART3/TIP110 NLS-mouse importin alpha complex==
==Crystal structure of human SART3/TIP110 NLS-mouse importin alpha complex==
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<StructureSection load='5ctt' size='340' side='right' caption='[[5ctt]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='5ctt' size='340' side='right'caption='[[5ctt]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ctt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CTT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CTT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ctt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CTT FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ctq|5ctq]], [[5ctr|5ctr]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ctt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ctt OCA], [http://pdbe.org/5ctt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ctt RCSB], [http://www.ebi.ac.uk/pdbsum/5ctt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ctt ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ctt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ctt OCA], [https://pdbe.org/5ctt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ctt RCSB], [https://www.ebi.ac.uk/pdbsum/5ctt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ctt ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/SART3_HUMAN SART3_HUMAN]] Defects in SART3 are the cause of disseminated superficial actinic porokeratosis type 1 (DSAP1) [MIM:[http://omim.org/entry/175900 175900]]. DSAP1 is an autosomal dominant disorder, characterized by multiple superficial keratotic lesions surrounded by a slightly raised keratotic border, developing during the third or fourth decade of life on sun-exposed areas of skin.<ref>PMID:15840095</ref>
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE]] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. [[http://www.uniprot.org/uniprot/SART3_HUMAN SART3_HUMAN]] Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.<ref>PMID:11959860</ref>
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[https://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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<div class="pdbe-citations 5ctt" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ctt" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Importin 3D structures|Importin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Kim, E E]]
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[[Category: Homo sapiens]]
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[[Category: Park, J K]]
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[[Category: Large Structures]]
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[[Category: Complex]]
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[[Category: Mus musculus]]
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[[Category: Immune system]]
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[[Category: Kim EE]]
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[[Category: Nuclear localization signal]]
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[[Category: Park JK]]
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[[Category: Nuclear protein]]
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[[Category: Protein transporter]]
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[[Category: Rna binding protein]]
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[[Category: Transport protein]]
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Current revision

Crystal structure of human SART3/TIP110 NLS-mouse importin alpha complex

PDB ID 5ctt

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