4z31

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==Crystal structure of the RC3H2 ROQ domain in complex with stem-loop and double-stranded forms of RNA==
==Crystal structure of the RC3H2 ROQ domain in complex with stem-loop and double-stranded forms of RNA==
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<StructureSection load='4z31' size='340' side='right' caption='[[4z31]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='4z31' size='340' side='right'caption='[[4z31]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4z31]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z31 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z31 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4z31]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z31 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z31 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z31 OCA], [http://pdbe.org/4z31 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z31 RCSB], [http://www.ebi.ac.uk/pdbsum/4z31 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z31 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z31 OCA], [https://pdbe.org/4z31 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z31 RCSB], [https://www.ebi.ac.uk/pdbsum/4z31 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z31 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RC3H2_HUMAN RC3H2_HUMAN]] Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity).
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[https://www.uniprot.org/uniprot/RC3H2_HUMAN RC3H2_HUMAN] Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Homo sapiens]]
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[[Category: Bountra, C]]
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[[Category: Large Structures]]
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[[Category: DONG, A]]
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[[Category: Arrowsmith CH]]
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[[Category: Edwards, A M]]
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[[Category: Bountra C]]
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[[Category: Structural genomic]]
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[[Category: DONG A]]
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[[Category: TEMPEL, W]]
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[[Category: Edwards AM]]
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[[Category: TONG, Y]]
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[[Category: TEMPEL W]]
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[[Category: ZHANG, Q]]
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[[Category: TONG Y]]
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[[Category: Rna]]
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[[Category: ZHANG Q]]
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[[Category: Rna binding protein-rna complex]]
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[[Category: Roquin2]]
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[[Category: Sgc]]
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Current revision

Crystal structure of the RC3H2 ROQ domain in complex with stem-loop and double-stranded forms of RNA

PDB ID 4z31

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