5jyy
From Proteopedia
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==Structure-based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-resistant Influenza Viruses== | ==Structure-based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-resistant Influenza Viruses== | ||
| - | <StructureSection load='5jyy' size='340' side='right' caption='[[5jyy]], [[Resolution|resolution]] 2.10Å' scene=''> | + | <StructureSection load='5jyy' size='340' side='right'caption='[[5jyy]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5jyy]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5e6l 5e6l]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYY OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5jyy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5e6l 5e6l]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JYY FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6PY:5-(ACETYLAMINO)-2,6-ANHYDRO-4-CARBAMIMIDAMIDO-3,4,5-TRIDEOXY-7-O-[(2-METHOXYETHYL)CARBAMOYL]-D-GLYCERO-D-GALACTO-NON-2-ENONIC+ACID'>6PY</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6PY:5-(ACETYLAMINO)-2,6-ANHYDRO-4-CARBAMIMIDAMIDO-3,4,5-TRIDEOXY-7-O-[(2-METHOXYETHYL)CARBAMOYL]-D-GLYCERO-D-GALACTO-NON-2-ENONIC+ACID'>6PY</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyy OCA], [https://pdbe.org/5jyy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jyy RCSB], [https://www.ebi.ac.uk/pdbsum/5jyy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyy ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/R4NFR6_9INFA R4NFR6_9INFA] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252] |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5jyy" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5jyy" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Neuraminidase 3D structures|Neuraminidase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Influenza A virus]] |
| - | [[Category: Bi | + | [[Category: Large Structures]] |
| - | [[Category: Fu | + | [[Category: Bi Y]] |
| - | [[Category: Gao | + | [[Category: Fu L]] |
| - | [[Category: Li | + | [[Category: Gao GF]] |
| - | [[Category: Li | + | [[Category: Li X]] |
| - | [[Category: Lu | + | [[Category: Li Y]] |
| - | [[Category: Lv | + | [[Category: Lu X]] |
| - | [[Category: Qi | + | [[Category: Lv X]] |
| - | [[Category: Wu | + | [[Category: Qi J]] |
| - | [[Category: Yan | + | [[Category: Wu Y]] |
| - | [[Category: Zhang | + | [[Category: Yan J]] |
| - | + | [[Category: Zhang S]] | |
| - | + | ||
| - | + | ||
Current revision
Structure-based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-resistant Influenza Viruses
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Categories: Influenza A virus | Large Structures | Bi Y | Fu L | Gao GF | Li X | Li Y | Lu X | Lv X | Qi J | Wu Y | Yan J | Zhang S
