5fzt

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==The crystal structure of R7R8 in complex with a DLC1 fragment.==
==The crystal structure of R7R8 in complex with a DLC1 fragment.==
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<StructureSection load='5fzt' size='340' side='right' caption='[[5fzt]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='5fzt' size='340' side='right'caption='[[5fzt]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fzt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FZT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fzt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FZT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fzt OCA], [http://pdbe.org/5fzt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fzt RCSB], [http://www.ebi.ac.uk/pdbsum/5fzt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fzt ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fzt OCA], [https://pdbe.org/5fzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fzt RCSB], [https://www.ebi.ac.uk/pdbsum/5fzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fzt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts. [[http://www.uniprot.org/uniprot/RHG07_HUMAN RHG07_HUMAN]] Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.<ref>PMID:18786931</ref> <ref>PMID:19170769</ref> <ref>PMID:19710422</ref>
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[https://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5fzt" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5fzt" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Talin 3D structures|Talin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Almeida, T]]
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[[Category: Almeida T]]
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[[Category: Ballestrem, C]]
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[[Category: Ballestrem C]]
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[[Category: Barsukov, I L]]
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[[Category: Barsukov IL]]
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[[Category: Critchley, D R]]
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[[Category: Critchley DR]]
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[[Category: Goult, B T]]
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[[Category: Goult BT]]
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[[Category: Jethwa, D]]
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[[Category: Jethwa D]]
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[[Category: Lowy, D R]]
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[[Category: Lowy DR]]
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[[Category: Qian, X]]
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[[Category: Qian X]]
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[[Category: Zacharchenko, T]]
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[[Category: Zacharchenko T]]
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[[Category: Dlc1]]
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[[Category: Focal adhesion]]
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[[Category: Structural protein]]
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[[Category: Talin]]
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Current revision

The crystal structure of R7R8 in complex with a DLC1 fragment.

PDB ID 5fzt

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