4zp3

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==AKAP18:PKA-RIIalpha structure reveals crucial anchor points for recognition of regulatory subunits of PKA==
==AKAP18:PKA-RIIalpha structure reveals crucial anchor points for recognition of regulatory subunits of PKA==
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<StructureSection load='4zp3' size='340' side='right' caption='[[4zp3]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
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<StructureSection load='4zp3' size='340' side='right'caption='[[4zp3]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zp3]] is a 18 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZP3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZP3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zp3]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZP3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.63&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zp3 OCA], [http://pdbe.org/4zp3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zp3 RCSB], [http://www.ebi.ac.uk/pdbsum/4zp3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zp3 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zp3 OCA], [https://pdbe.org/4zp3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zp3 RCSB], [https://www.ebi.ac.uk/pdbsum/4zp3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zp3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KAP2_HUMAN KAP2_HUMAN]] Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. [[http://www.uniprot.org/uniprot/AKA7A_HUMAN AKA7A_HUMAN]] Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.<ref>PMID:10613906</ref> <ref>PMID:17244820</ref> <ref>PMID:9545239</ref>
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[https://www.uniprot.org/uniprot/AKA7G_HUMAN AKA7G_HUMAN] Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.<ref>PMID:10613906</ref> <ref>PMID:17244820</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4zp3" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4zp3" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[A-kinase anchor protein|A-kinase anchor protein]]
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*[[A-kinase anchor protein 3D structures|A-kinase anchor protein 3D structures]]
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*[[CAMP-dependent protein kinase 3D structures|CAMP-dependent protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Autenrieth, K]]
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[[Category: Homo sapiens]]
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[[Category: Daumke, O]]
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[[Category: Large Structures]]
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[[Category: Faelber, K]]
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[[Category: Autenrieth K]]
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[[Category: Goetz, F]]
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[[Category: Daumke O]]
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[[Category: Heinemann, U]]
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[[Category: Faelber K]]
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[[Category: Herberg, F W]]
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[[Category: Goetz F]]
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[[Category: Klussmann, E]]
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[[Category: Heinemann U]]
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[[Category: Krause, G]]
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[[Category: Herberg FW]]
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[[Category: Kreuchwig, A]]
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[[Category: Klussmann E]]
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[[Category: Roske, Y]]
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[[Category: Krause G]]
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[[Category: Zuehlke, K]]
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[[Category: Kreuchwig A]]
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[[Category: Akap]]
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[[Category: Roske Y]]
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[[Category: Amphiphathic helix]]
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[[Category: Zuehlke K]]
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[[Category: Anchor point]]
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[[Category: Dd-domain]]
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[[Category: Signaling protein]]
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Current revision

AKAP18:PKA-RIIalpha structure reveals crucial anchor points for recognition of regulatory subunits of PKA

PDB ID 4zp3

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