1jjo

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[[Image:1jjo.gif|left|200px]]
 
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{{Structure
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==Crystal Structure of Mouse Neuroserpin (Cleaved form)==
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|PDB= 1jjo |SIZE=350|CAPTION= <scene name='initialview01'>1jjo</scene>, resolution 3.06&Aring;
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<StructureSection load='1jjo' size='340' side='right'caption='[[1jjo]], [[Resolution|resolution]] 3.06&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1jjo]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JJO FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.06&#8491;</td></tr>
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|GENE= SERPINI1 or PI12 or SPI17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jjo OCA], [https://pdbe.org/1jjo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jjo RCSB], [https://www.ebi.ac.uk/pdbsum/1jjo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jjo ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jjo OCA], [http://www.ebi.ac.uk/pdbsum/1jjo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jjo RCSB]</span>
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[https://www.uniprot.org/uniprot/NEUS_MOUSE NEUS_MOUSE] Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/1jjo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jjo ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of Mouse Neuroserpin (Cleaved form)'''
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==See Also==
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*[[Serpin 3D structures|Serpin 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The protease inhibitor neuroserpin regulates the development of the nervous system and its plasticity in the adult. Neuroserpins carrying the Ser53Pro or Ser56Arg mutation form polymers in neuronal cells. We describe here the structure of wild-type neuroserpin in a cleaved form. The structure provides a basis to understand the role of the mutations in the polymerization process. We propose that these mutations could delay the insertion of the reactive center loop into the central beta-sheet A, an essential step in the inhibition and possibly in the polymerization of neuroserpin.
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[[Category: Large Structures]]
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==About this Structure==
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1JJO is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JJO OCA].
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==Reference==
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Crystal structure of neuroserpin: a neuronal serpin involved in a conformational disease., Briand C, Kozlov SV, Sonderegger P, Grutter MG, FEBS Lett. 2001 Sep 7;505(1):18-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11557034 11557034]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Briand C]]
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[[Category: Briand, C.]]
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[[Category: Gruetter MG]]
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[[Category: Gruetter, M G.]]
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[[Category: Kozlov SV]]
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[[Category: Kozlov, S V.]]
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[[Category: Sonderegger P]]
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[[Category: Sonderegger, P.]]
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[[Category: neuronal serpin]]
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[[Category: serine protease inhibitor]]
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[[Category: serpin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:34:37 2008''
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Current revision

Crystal Structure of Mouse Neuroserpin (Cleaved form)

PDB ID 1jjo

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