This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5ixd

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:36, 6 September 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Structure of human JAK1 FERM/SH2 in complex with IFN lambda receptor==
==Structure of human JAK1 FERM/SH2 in complex with IFN lambda receptor==
-
<StructureSection load='5ixd' size='340' side='right' caption='[[5ixd]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
+
<StructureSection load='5ixd' size='340' side='right'caption='[[5ixd]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5ixd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IXD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IXD FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5ixd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IXD FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ixi|5ixi]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ixd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ixd OCA], [https://pdbe.org/5ixd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ixd RCSB], [https://www.ebi.ac.uk/pdbsum/5ixd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ixd ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ixd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ixd OCA], [http://pdbe.org/5ixd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ixd RCSB], [http://www.ebi.ac.uk/pdbsum/5ixd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ixd ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN]] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. [[http://www.uniprot.org/uniprot/INLR1_HUMAN INLR1_HUMAN]] The IFNLR1/IL10RB dimer is a receptor for IFNL1, IFNL2 and IFNL3. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.<ref>PMID:12521379</ref> <ref>PMID:12469119</ref> <ref>PMID:12483210</ref>
+
[https://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 20: Line 19:
</div>
</div>
<div class="pdbe-citations 5ixd" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ixd" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Interferon receptor 3D structures|Interferon receptor 3D structures]]
 +
*[[Janus kinase 3D structures|Janus kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Non-specific protein-tyrosine kinase]]
+
[[Category: Homo sapiens]]
-
[[Category: Ferrao, R]]
+
[[Category: Large Structures]]
-
[[Category: Lupardus, P J]]
+
[[Category: Ferrao R]]
-
[[Category: Wallweber, H J.A]]
+
[[Category: Lupardus PJ]]
-
[[Category: Cytokine]]
+
[[Category: Wallweber HJA]]
-
[[Category: Ifnlr1]]
+
-
[[Category: Interferon]]
+
-
[[Category: Jak kinase]]
+
-
[[Category: Jak1]]
+

Current revision

Structure of human JAK1 FERM/SH2 in complex with IFN lambda receptor

PDB ID 5ixd

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5ixd"
Personal tools