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1jl6

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[[Image:1jl6.jpg|left|200px]]
 
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{{Structure
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==Crystal Structure of CN-Ligated Component IV Glycera Dibranchiata Monomeric Hemoglobin==
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|PDB= 1jl6 |SIZE=350|CAPTION= <scene name='initialview01'>1jl6</scene>, resolution 1.4&Aring;
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<StructureSection load='1jl6' size='340' side='right'caption='[[1jl6]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>
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<table><tr><td colspan='2'>[[1jl6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Glycera_dibranchiata Glycera dibranchiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JL6 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jl6 OCA], [https://pdbe.org/1jl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jl6 RCSB], [https://www.ebi.ac.uk/pdbsum/1jl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jl6 ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jl6 OCA], [http://www.ebi.ac.uk/pdbsum/1jl6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jl6 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/GLB4_GLYDI GLB4_GLYDI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jl/1jl6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jl6 ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of CN-Ligated Component IV Glycera Dibranchiata Monomeric Hemoglobin'''
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==See Also==
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*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Erythrocytes of the marine annelid, Glycera dibranchiata, contain a mixture of monomeric and polymeric hemoglobins. There are three major monomer hemoglobin components, II, III, IV (also called GMH2, 3, and 4), that have been highly purified and well characterized. We have now crystallized GMH3 and GMH4 and determined their structures to 1.4-1.8 A resolution. The structures were determined for these two monomer hemoglobins in the oxidized (Fe3+, ferric, or met-) forms in both the unligated and cyanide-ligated states. This work differs from two published, refined structures of a Glycera dibranchiata monomer hemoglobin, which has a sequence that is substantially different from any bona fide major monomer hemoglobins (GMH2, 3, or 4). The high-resolution crystal structures (presented here) and the previous NMR structure of CO-ligated GMH4, provide a basis for interpreting structure/function details of the monomer hemoglobins. These details include: (1) the strong correlation between temperature factor and NMR dynamics for respective protein forms; (2) the unique nature of the HisE7Leu primary sequence substitutions in GMH3 and GMH4 and their impact on cyanide ion binding kinetics; (3) the LeuB10Phe difference between GMH3 and GMH4 and its impact on ligand binding; and (4) elucidation of changes in the structural details of the distal and proximal heme pockets upon cyanide binding.
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==About this Structure==
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1JL6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Glycera_dibranchiata Glycera dibranchiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JL6 OCA].
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==Reference==
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Crystal structures of unligated and CN-ligated Glycera dibranchiata monomer ferric hemoglobin components III and IV., Park HJ, Yang C, Treff N, Satterlee JD, Kang C, Proteins. 2002 Oct 1;49(1):49-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12211015 12211015]
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[[Category: Glycera dibranchiata]]
[[Category: Glycera dibranchiata]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Kang, C.]]
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[[Category: Kang C]]
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[[Category: Park, H J.]]
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[[Category: Park HJ]]
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[[Category: Satterlee, J D.]]
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[[Category: Satterlee JD]]
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[[Category: Treff, N.]]
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[[Category: Treff N]]
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[[Category: Yang, C.]]
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[[Category: Yang C]]
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[[Category: glycera]]
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[[Category: monomer hemoglobin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:35:15 2008''
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Current revision

Crystal Structure of CN-Ligated Component IV Glycera Dibranchiata Monomeric Hemoglobin

PDB ID 1jl6

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