5jw8
From Proteopedia
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==Crystal structure of the Type IV pilin subunit PilE from Neisseria meningitidis== | ==Crystal structure of the Type IV pilin subunit PilE from Neisseria meningitidis== | ||
| - | <StructureSection load='5jw8' size='340' side='right' caption='[[5jw8]], [[Resolution|resolution]] 1.44Å' scene=''> | + | <StructureSection load='5jw8' size='340' side='right'caption='[[5jw8]], [[Resolution|resolution]] 1.44Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5jw8]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4xnp 4xnp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JW8 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5jw8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis_8013 Neisseria meningitidis 8013]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4xnp 4xnp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JW8 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.439Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jw8 OCA], [https://pdbe.org/5jw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jw8 RCSB], [https://www.ebi.ac.uk/pdbsum/5jw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jw8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A1C7D1B2_NEIM8 A0A1C7D1B2_NEIM8] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Neisseria meningitidis use Type IV pili (T4P) to adhere to endothelial cells and breach the blood brain barrier, causing cause fatal meningitis. T4P are multifunctional polymers of the major pilin protein, which share a conserved hydrophobic N terminus that is a curved extended alpha-helix, alpha1, in X-ray crystal structures. Here we report a 1.44 A crystal structure of the N. meningitidis major pilin PilE and a approximately 6 A cryo-electron microscopy reconstruction of the intact pilus, from which we built an atomic model for the filament. This structure reveals the molecular arrangement of the N-terminal alpha-helices in the filament core, including a melted central portion of alpha1 and a bridge of electron density consistent with a predicted salt bridge necessary for pilus assembly. This structure has important implications for understanding pilus biology. | ||
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| + | Structure of the Neisseria meningitidis Type IV pilus.,Kolappan S, Coureuil M, Yu X, Nassif X, Egelman EH, Craig L Nat Commun. 2016 Oct 4;7:13015. doi: 10.1038/ncomms13015. PMID:27698424<ref>PMID:27698424</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5jw8" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Pilin 3D structures|Pilin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Neisseria meningitidis 8013]] |
| - | [[Category: | + | [[Category: Craig L]] |
| - | [[Category: | + | [[Category: Kolappan S]] |
Current revision
Crystal structure of the Type IV pilin subunit PilE from Neisseria meningitidis
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