1jox

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[[Image:1jox.gif|left|200px]]
 
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{{Structure
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==NMR Structure of the LP5.1 Hairpin from Bacillus RNase P RNA Refined with Residual Dipolar Couplings==
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|PDB= 1jox |SIZE=350|CAPTION= <scene name='initialview01'>1jox</scene>
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<StructureSection load='1jox' size='340' side='right'caption='[[1jox]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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<table><tr><td colspan='2'>[[1jox]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JOX FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jox OCA], [https://pdbe.org/1jox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jox RCSB], [https://www.ebi.ac.uk/pdbsum/1jox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jox ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=[[1jp0|1JP0]]
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<div style="background-color:#fffaf0;">
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jox OCA], [http://www.ebi.ac.uk/pdbsum/1jox PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jox RCSB]</span>
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== Publication Abstract from PubMed ==
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}}
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'''NMR Structure of the LP5.1 Hairpin from Bacillus RNase P RNA Refined with Residual Dipolar Couplings'''
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==Overview==
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Long-range interactions involving the P5.1 hairpin of Bacillus RNase P RNA are thought to form a structural truss to support RNA folding and activity. We determined the structure of this element by NMR and refined the structure using residual dipolar couplings from a sample weakly oriented in a dilute liquid crystalline mixture of polyethylene glycol and hexanol. Dipolar coupling refinement improved the global precision of the structure from 1.5 to 1.2 A (to the mean), revised the bend angle between segments of the P5.1 stem and corroborated the structure of the loop region. The UGAGAU hexaloop of P5.1 contains two stacks of bases on opposite sides of the loop, distinguishing it from GNRA tetraloops. The unusual conformation of the juxtaposed uracil residues within the hexaloop may explain their requirement in transactivation assays.
Long-range interactions involving the P5.1 hairpin of Bacillus RNase P RNA are thought to form a structural truss to support RNA folding and activity. We determined the structure of this element by NMR and refined the structure using residual dipolar couplings from a sample weakly oriented in a dilute liquid crystalline mixture of polyethylene glycol and hexanol. Dipolar coupling refinement improved the global precision of the structure from 1.5 to 1.2 A (to the mean), revised the bend angle between segments of the P5.1 stem and corroborated the structure of the loop region. The UGAGAU hexaloop of P5.1 contains two stacks of bases on opposite sides of the loop, distinguishing it from GNRA tetraloops. The unusual conformation of the juxtaposed uracil residues within the hexaloop may explain their requirement in transactivation assays.
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==About this Structure==
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Structure of the UGAGAU hexaloop that braces Bacillus RNase P for action.,Leeper TC, Martin MB, Kim H, Cox S, Semenchenko V, Schmidt FJ, Van Doren SR Nat Struct Biol. 2002 May;9(5):397-403. PMID:11927952<ref>PMID:11927952</ref>
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1JOX is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOX OCA].
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==Reference==
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Structure of the UGAGAU hexaloop that braces Bacillus RNase P for action., Leeper TC, Martin MB, Kim H, Cox S, Semenchenko V, Schmidt FJ, Van Doren SR, Nat Struct Biol. 2002 May;9(5):397-403. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11927952 11927952]
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[[Category: Protein complex]]
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[[Category: Doren, S R.Van.]]
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[[Category: Leeper, T C.]]
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[[Category: Schmidt, F J.]]
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[[Category: hairpin]]
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[[Category: residual dipolar coupling refinement]]
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[[Category: ribonucleic acid]]
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[[Category: rnase p]]
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[[Category: ugnrau]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:36:49 2008''
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1jox" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Leeper TC]]
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[[Category: Schmidt FJ]]
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[[Category: Van Doren SR]]

Current revision

NMR Structure of the LP5.1 Hairpin from Bacillus RNase P RNA Refined with Residual Dipolar Couplings

PDB ID 1jox

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