5hvh

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==Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with two Inhibitory Nanobodies==
==Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with two Inhibitory Nanobodies==
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<StructureSection load='5hvh' size='340' side='right' caption='[[5hvh]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='5hvh' size='340' side='right'caption='[[5hvh]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5hvh]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HVH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HVH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5hvh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HVH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HVH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hvf|5hvf]], [[5hvg|5hvg]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_U Carboxypeptidase U], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.20 3.4.17.20] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hvh OCA], [https://pdbe.org/5hvh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hvh RCSB], [https://www.ebi.ac.uk/pdbsum/5hvh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hvh ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hvh OCA], [http://pdbe.org/5hvh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hvh RCSB], [http://www.ebi.ac.uk/pdbsum/5hvh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hvh ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CBPB2_HUMAN CBPB2_HUMAN]] Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.<ref>PMID:10574983</ref>
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[https://www.uniprot.org/uniprot/CBPB2_HUMAN CBPB2_HUMAN] Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.<ref>PMID:10574983</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5hvh" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5hvh" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[Carboxypeptidase 3D structures|Carboxypeptidase 3D structures]]
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Carboxypeptidase U]]
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[[Category: Homo sapiens]]
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[[Category: Declerck, P J]]
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[[Category: Large Structures]]
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[[Category: Strelkov, S V]]
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[[Category: Vicugna pacos]]
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[[Category: Weeks, S D]]
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[[Category: Declerck PJ]]
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[[Category: Zhou, X]]
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[[Category: Strelkov SV]]
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[[Category: Antibody fragment]]
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[[Category: Weeks SD]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Zhou X]]
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[[Category: Hydrolase/hydrolase inhibitor]]
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[[Category: Nanobody]]
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[[Category: Plasma procarboxypeptidase b]]
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[[Category: Procarboxypeptidase r]]
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[[Category: Procarboxypeptidase u]]
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[[Category: Protein complex]]
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[[Category: Tafi]]
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[[Category: Thrombin-activatable fibrinolysis inhibitor]]
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Current revision

Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with two Inhibitory Nanobodies

PDB ID 5hvh

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