4z33
From Proteopedia
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==Crystal structure of the syntenin PDZ1 and PDZ2 tandem in complex with the Frizzled 7 C-terminal fragment and PIP2== | ==Crystal structure of the syntenin PDZ1 and PDZ2 tandem in complex with the Frizzled 7 C-terminal fragment and PIP2== | ||
| - | <StructureSection load='4z33' size='340' side='right' caption='[[4z33]], [[Resolution|resolution]] 2.45Å' scene=''> | + | <StructureSection load='4z33' size='340' side='right'caption='[[4z33]], [[Resolution|resolution]] 2.45Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4z33]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z33 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4z33]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z33 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IP2:D-MYO-INOSITOL-4,5-BISPHOSPHATE'>IP2</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IP2:D-MYO-INOSITOL-4,5-BISPHOSPHATE'>IP2</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z33 OCA], [https://pdbe.org/4z33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z33 RCSB], [https://www.ebi.ac.uk/pdbsum/4z33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z33 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/FZD7_HUMAN FZD7_HUMAN] Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
| - | == | + | |
| - | + | ==See Also== | |
| + | *[[3D structures of syntenin|3D structures of syntenin]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Egea-Jimenez | + | [[Category: Homo sapiens]] |
| - | [[Category: Gallardo | + | [[Category: Large Structures]] |
| - | [[Category: Garcia-Pino | + | [[Category: Egea-Jimenez AL]] |
| - | [[Category: Ivarsson | + | [[Category: Gallardo R]] |
| - | [[Category: Kashyap | + | [[Category: Garcia-Pino A]] |
| - | [[Category: Loris | + | [[Category: Ivarsson Y]] |
| - | [[Category: Rousseau | + | [[Category: Kashyap R]] |
| - | [[Category: Schymkowitz | + | [[Category: Loris R]] |
| - | [[Category: Wawrzyniak | + | [[Category: Rousseau F]] |
| - | [[Category: Zimmermann | + | [[Category: Schymkowitz J]] |
| - | + | [[Category: Wawrzyniak AM]] | |
| - | + | [[Category: Zimmermann P]] | |
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Current revision
Crystal structure of the syntenin PDZ1 and PDZ2 tandem in complex with the Frizzled 7 C-terminal fragment and PIP2
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