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1jr1

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[[Image:1jr1.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid==
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|PDB= 1jr1 |SIZE=350|CAPTION= <scene name='initialview01'>1jr1</scene>, resolution 2.6&Aring;
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<StructureSection load='1jr1' size='340' side='right'caption='[[1jr1]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MOA:MYCOPHENOLIC+ACID'>MOA</scene>
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<table><tr><td colspan='2'>[[1jr1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JR1 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MOA:MYCOPHENOLIC+ACID'>MOA</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr1 OCA], [https://pdbe.org/1jr1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jr1 RCSB], [https://www.ebi.ac.uk/pdbsum/1jr1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jr1 ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1ak5|1AK5]], [[1b3o|1B3O]], [[1zfj|1ZFJ]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr1 OCA], [http://www.ebi.ac.uk/pdbsum/1jr1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jr1 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/IMDH2_CRIGR IMDH2_CRIGR] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (By similarity). It may also have a role in the development of malignancy and the growth progression of some tumors.[HAMAP-Rule:MF_03156]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/1jr1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jr1 ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid'''
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==See Also==
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*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The structure of inosine-5'-monophosphate dehydrogenase (IMPDH) in complex with IMP and mycophenolic acid (MPA) has been determined by X-ray diffraction. IMPDH plays a central role in B and T lymphocyte replication. MPA is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug recently approved for the treatment of allograft rejection. IMPDH comprises two domains: a core domain, which is an alpha/beta barrel and contains the active site, and a flanking domain. The complex, in combination with mutagenesis and kinetic data, provides a structural basis for understanding the mechanism of IMPDH activity and indicates that MPA inhibits IMPDH by acting as a replacement for the nicotinamide portion of the nicotinamide adenine dinucleotide cofactor and a catalytic water molecule.
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==About this Structure==
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1JR1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR1 OCA].
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==Reference==
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Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid., Sintchak MD, Fleming MA, Futer O, Raybuck SA, Chambers SP, Caron PR, Murcko MA, Wilson KP, Cell. 1996 Jun 14;85(6):921-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8681386 8681386]
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[[Category: Cricetulus griseus]]
[[Category: Cricetulus griseus]]
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[[Category: IMP dehydrogenase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Caron PR]]
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[[Category: Caron, P R.]]
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[[Category: Chambers SP]]
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[[Category: Chambers, S P.]]
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[[Category: Fleming MA]]
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[[Category: Fleming, M A.]]
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[[Category: Futer O]]
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[[Category: Futer, O.]]
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[[Category: Murcko MA]]
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[[Category: Murcko, M A.]]
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[[Category: Raybuck SA]]
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[[Category: Raybuck, S A.]]
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[[Category: Sintchak MD]]
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[[Category: Sintchak, M D.]]
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[[Category: Wilson KP]]
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[[Category: Wilson, K P.]]
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[[Category: dehydrogenase]]
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[[Category: guanine nucleotide synthesis]]
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[[Category: impd]]
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[[Category: impdh]]
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[[Category: mpa]]
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[[Category: mycophenolic acid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:37:44 2008''
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Current revision

Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid

PDB ID 1jr1

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