1juv

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[[Image:1juv.gif|left|200px]]
 
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{{Structure
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==Crystal structure analysis of Dihydrofolate reductase from Bacteriophage T4==
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|PDB= 1juv |SIZE=350|CAPTION= <scene name='initialview01'>1juv</scene>, resolution 1.70&Aring;
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<StructureSection load='1juv' size='340' side='right'caption='[[1juv]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>
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<table><tr><td colspan='2'>[[1juv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JUV FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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|GENE= frd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 Enterobacteria phage T4])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1juv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1juv OCA], [https://pdbe.org/1juv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1juv RCSB], [https://www.ebi.ac.uk/pdbsum/1juv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1juv ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1juv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1juv OCA], [http://www.ebi.ac.uk/pdbsum/1juv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1juv RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/DYR_BPT4 DYR_BPT4] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/1juv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1juv ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure analysis of Dihydrofolate reductase from Bacteriophage T4'''
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==See Also==
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1JUV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUV OCA].
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[[Category: Escherichia virus T4]]
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[[Category: Dihydrofolate reductase]]
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[[Category: Large Structures]]
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[[Category: Enterobacteria phage t4]]
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[[Category: Moon JH]]
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[[Category: Single protein]]
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[[Category: Oh YK]]
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[[Category: Moon, J H.]]
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[[Category: Suh SW]]
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[[Category: Oh, Y K.]]
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[[Category: Suh, S W.]]
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[[Category: complexed with nadph]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:39:25 2008''
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Current revision

Crystal structure analysis of Dihydrofolate reductase from Bacteriophage T4

PDB ID 1juv

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