1jxv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:16, 25 October 2023) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1jxv.gif|left|200px]]
 
-
{{Structure
+
==Crystal Structure of Human Nucleoside Diphosphate Kinase A==
-
|PDB= 1jxv |SIZE=350|CAPTION= <scene name='initialview01'>1jxv</scene>, resolution 2.2&Aring;
+
<StructureSection load='1jxv' size='340' side='right'caption='[[1jxv]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[1jxv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JXV FirstGlance]. <br>
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-diphosphate_kinase Nucleoside-diphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.6 2.7.4.6] </span>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
|GENE= nm23-H1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jxv OCA], [https://pdbe.org/1jxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jxv RCSB], [https://www.ebi.ac.uk/pdbsum/1jxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jxv ProSAT]</span></td></tr>
-
|DOMAIN=
+
</table>
-
|RELATEDENTRY=
+
== Function ==
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jxv OCA], [http://www.ebi.ac.uk/pdbsum/1jxv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jxv RCSB]</span>
+
[https://www.uniprot.org/uniprot/NDKA_HUMAN NDKA_HUMAN] Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.<ref>PMID:2056128</ref> <ref>PMID:8810265</ref> <ref>PMID:12628186</ref>
-
}}
+
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/1jxv_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jxv ConSurf].
 +
<div style="clear:both"></div>
-
'''Crystal Structure of Human Nucleoside Diphosphate Kinase A'''
+
==See Also==
-
 
+
*[[Nucleoside diphosphate kinase 3D structures|Nucleoside diphosphate kinase 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
1JXV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXV OCA].
+
__TOC__
-
 
+
</StructureSection>
-
==Reference==
+
-
Crystal structure of human nucleoside diphosphate kinase A, a metastasis suppressor., Min K, Song HK, Chang C, Kim SY, Lee KJ, Suh SW, Proteins. 2002 Feb 15;46(3):340-2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11835509 11835509]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Nucleoside-diphosphate kinase]]
+
[[Category: Large Structures]]
-
[[Category: Single protein]]
+
[[Category: Chang C]]
-
[[Category: Chang, C.]]
+
[[Category: Kim SY]]
-
[[Category: Kim, S Y.]]
+
[[Category: Lee KJ]]
-
[[Category: Lee, K J.]]
+
[[Category: Min K]]
-
[[Category: Min, K.]]
+
[[Category: Song HK]]
-
[[Category: Song, H K.]]
+
[[Category: Suh SW]]
-
[[Category: Suh, S W.]]
+
-
[[Category: kinase]]
+
-
[[Category: transferase]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:40:31 2008''
+

Current revision

Crystal Structure of Human Nucleoside Diphosphate Kinase A

PDB ID 1jxv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jxv"
Personal tools